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Study Shows How Genetic Variations Can Enhance Cancer Drug Effectiveness

By exploiting the genetic variation in cancer cells, an already approved cancer drug demonstrated enhanced effects against cancer cells in specific patient groups.

15 Nov 2024

AI Tool Predicts Gene Activity from Tumor Images to Guide Treatment

To determine the type and severity of a cancer, pathologists typically analyze thin slices of a tumor biopsy under a microscope.

15 Nov 2024

Caterpillar Fungus Compound Blocks Cancer Growth Signals Within 30 Minutes

Cordycepin, derived from fungi, shows promise in cancer therapy by inhibiting growth factor signaling pathways critical for cell proliferation and survival.

15 Nov 2024

Researchers Uncover Valuable Genetic Diversity in Barley Pangenome

Reliable crop yields fueled the rise of human civilizations. As people embraced a new way of life, cultivated plants, too, had to adapt to the needs of their domesticators.

14 Nov 2024

Study Reveals How Simple Molecules Could Have Formed Early Cell Membranes

Few questions have captivated humankind more than the origin of life on Earth. How did the first living cells come to exist? How did these early protocells develop the structural membranes necessary for cells to thrive and assemble into complex organisms?

14 Nov 2024

Supercomputer Simulations Uncover Key Proteins in Membrane Recycling

Newly discovered mechanism helps detach and recycle parts of cellular canal membranes as needed – models developed using supercomputer simulations.

14 Nov 2024

New Bioluminescent Proteins Enable Excitation-Free Imaging in Living Organisms

Bioluminescence is the natural chemical process of light creation in some living creatures that makes fireflies flicker and some jellyfish glow.

14 Nov 2024

Unveiling the Clinical Significance of Microbial Load in Human Health

Scientists built a new machine-learning model to predict microbial load — the density of microorganisms in the guts — and used it to explain how microbial load plays an essential role in disease-microbiome relationships.

14 Nov 2024

Novel Approach to Combat Protein-Related Diseases

Researchers from Mainz and Leiden universities have devised a simple model system that can be used to break down fibrils, the cause of several diseases like Alzheimer's and Parkinson's disease, into their constituent single units or liquid droplets.

14 Nov 2024

Integrative Taxonomy Uncovers Cryptic Daisy Species

Sometimes plants are sufficiently similar to one another that the procedures used by 18th-century scientist Carl Linnaeus for distinguishing species are insufficient.

14 Nov 2024

Bioengineered Yeast Achieves Breakthrough in Mass-Producing Herbal Medicine

Herbal medicine is difficult to produce on an industrial scale. A team of Kobe University bioengineers manipulated the cellular machinery in a species of yeast so that one such molecule can now be produced in a fermenter at unprecedented concentrations.

14 Nov 2024

Engineering Cyanobacteria for Enhanced Ethanol Production

Researchers are investigating the creation of biofuel from microorganisms as a result of the increased need for sustainable fuel alternatives worldwide.

13 Nov 2024

New Insights into the Role of Chromatin in Cellular Processes

The Mattiroli group's researchers discovered that the speed at which DNA is replicated during cell division can be directly influenced by the way DNA is packaged in cells.

13 Nov 2024

A Closer Look at CAR T-Cell Therapy — Successes, Challenges, And Future

Chimeric antigen receptor T-cell therapy enhances immune response against cancer, with promising results in hematological malignancies and ongoing advancements.

13 Nov 2024

Groundbreaking Research Sheds Light on Mutant RAS and Cancer Progression

Researchers at the National Institutes of Health (NIH) and their collaborators have discovered a new way in which RAS genes, which are commonly mutated in cancer, may drive tumor growth beyond their well-known role in signaling at the cell surface.

12 Nov 2024

New Strategy Reinvigorates Exhausted T Cells to Fight Cancer

As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells -; which have lost their cancer-fighting oomph -; consume this lactic acid, which further saps their energy, according to new research from the University of Pittsburgh and UPMC Hillman Cancer Center.

11 Nov 2024