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Discovery of Lysosomal Vacuolation Mechanism Sheds Light on Aging and Disease

New research, published today in the journal Science, shows how lysosomes - organelles that act like cells' waste disposal system - respond to stress by becoming abnormally bloated, a process called lysosomal vacuolation that is associated with numerous diseases.

22 Aug 2025

Comprehensive Guide Sets New Standards for Plant Fluorescence Imaging

A team of expert scientists led by Kirk Czymmek, PhD, director of the Advanced Bioimaging Laboratory at the Donald Danforth Plant Science Center and Heather E. McFarlane, assistant professor at the University of Toronto and collaborators from the Danforth Center, University of Leeds (UK), University of Massachusetts (Amherst), University of California - Davis, University of Naples Federico II, University of Minnesota and Université de Montréal, have authored a comprehensive guide to elevate the quality, transparency, and reproducibility of fluorescence microscopy in plant research. The guide was recently published in the journal Plant Cell, "Best Practices in Plant Fluorescence Imaging and Reporting: A Primer"

22 Aug 2025

Atomic Force Microscopy and AI Transform Understanding of Tangled DNA

At school, it's often presented as a tidy double helix but scientists are revealing the varied and intricate shapes of DNA molecules.

22 Aug 2025

Breakthrough Technique Enables Large-Scale Study of Polar and Ionic Metabolites

Researchers from the McCullagh Group in Oxford University's Department of Chemistry have published an innovative method in Nature Protocols today (22 August) that provides comprehensive analysis of metabolites found in cells, tissues and biofluids.

22 Aug 2025

Mapping Kidney Cells Opens Path to Precision Medicine

A research team led by Indiana University School of Medicine physician scientists has made significant progress in mapping kidney cells that may one day allow for more accurate disease diagnosis.

22 Aug 2025

Genetic Insights from Wild Crop Relatives may Help Secure Future Food Supplies

With climate change and more frequent extreme weather events, researchers predict that global yields of important crops like maize, rice, and soybeans could decline by 12 to 20% by the end of the century.

22 Aug 2025

Mitsui, QSimulate, and Quantinuum Launch “QIDO”: A Quantum-Integrated Chemistry Platform Targeting Faster Drug and Materials Discovery

Mitsui & Co., Ltd. (“Mitsui”), QSimulate, and Quantinuum today announced the launch of a new quantum-integrated chemistry platform, QIDO (Quantum-Integrated Discovery Orchestrator).

From Quantinuum Ltd 22 Aug 2025

Epigenetic Noise Enables Cells to Shift Identity and Influence Immunity

All cells in the body contain the same DNA, but different cell types express different genes; skin cells express genes for the skin, liver cells express liver genes, and so on.

21 Aug 2025

Single-Cell Map Reveals Epigenomic Regulation of Human Fat Tissue

A new study has created the first single-cell map of how DNA is regulated and organized inside different cell-types of human fat tissue.

21 Aug 2025

Machine Learning Model Accounts for Biological Variability in Culture Media Design

Cell culture is a foundational technology widely used across fields such as pharmaceutical production, regenerative medicine, food science, and materials engineering. A critical component of successful cell culture is the culture medium-a solution containing essential nutrients that support cell growth.

21 Aug 2025

Computational Modeling Creates a Database for Improved Detection of Designer Drugs

How do you identify something no one has a test for? Designer drugs replicate the effects of known, illicit drugs but evade law enforcement.

21 Aug 2025

Cancer Cells Steal Energy from Fat to Fuel Growth

UCSF scientists caught cancer cells in the act of breaking into fat cells and releasing their fat. The energy heist seems to be critical for the growth of deadly breast cancer.

21 Aug 2025

How Primary Cilia Shape the Fate of Fat Precursor Cells

Too much fat can be unhealthy: how fat cells, so-called adipocytes, develop, is crucial for the function of the fat tissue.

21 Aug 2025

ISS National Lab-Sponsored Experiment Tests 3D Bioprinted Tissue for Growing Artificial Livers

To explore how 3D bioprinted liver tissue constructs complete with vascular channels behave in microgravity, the Wake Forest Institute for Regenerative Medicine (WFIRM) is sending an investigation to the International Space Station (ISS).

21 Aug 2025

Salk Researchers Create First Genetic Atlas to Span the Entire Arabidopsis Life Cycle

Nearly everything you know about plants was first discovered in a plant you've likely never heard of. Arabidopsis thaliana, also known as thale cress, is a small, flowering weed that has shaped much of plant biology as we know it.

20 Aug 2025

New Tool Offers Insight Into When Genes Turn On and Off in the Brain

A Yale research team has created a new computer tool that can pinpoint when exactly genes turn on and off over time during brain development - a finding that may one day help doctors identify the optimal window to deploy gene therapy treatments.

20 Aug 2025

New Technology Maps Over 140 Proteins Across Human Tissues

Each organ in the human body contains different types of cells arranged in specific ways.

20 Aug 2025

MIT Researchers Unlock the Hidden Features of Protein Language Models

Within the past few years, models that can predict the structure or function of proteins have been widely used for a variety of biological applications, such as identifying drug targets and designing new therapeutic antibodies.

20 Aug 2025

New Research on Amylin Could Pave the Way for Next-Generation Obesity Drugs

Amylin, a hormone that regulates both appetite and blood sugar by activating three distinct brain receptors, might serve as the foundation for the next generation of obesity drugs.

20 Aug 2025