Cell Line News and Research

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Light-Activated AR3 Triggers Alkalinity-Driven Apoptosis in Cancer Cells

One of the hallmarks of cancer cells is their ability to evade apoptosis, or programmed cell death, through changes in protein expression.

2 Dec 2025

UBQLN2 Liquid Droplets Found to Catalyze Early α-Synuclein Aggregation

Parkinson's disease (PD) is an age-related, progressive neurodegenerative disorder. The hallmark of PD pathogenesis is the Lewy bodies (LBs) that accumulate in neurons in the substantia nigra region of the brain, damaging these neurons and leading to the motor symptoms of the disease. α-synuclein (α-syn), a misfolded protein, aggregates and forms fibrils, which leads to the formation of LBs.

27 Nov 2025

Uncovering the Mechanism of Chromosome Congression for Targeted Cancer Therapy

A research team from The University of Osaka, in collaboration with the Massachusetts Institute of Technology, has uncovered a new molecular mechanism underlying chromosome alignment during cell division.

11 Nov 2025

Breakthrough in Understanding How Tick-Borne Encephalitis Virus Infects Human Brain Cells

The protein on human cells that tick-borne encephalitis virus (TBEV) uses for infection has now been identified-a major step toward understanding how TBEV causes neurological disease and for developing antiviral drugs.

3 Oct 2025

Actin Scaffold Protects Cancer Cell Nuclei Under Mechanical Stress

Researchers from the Cluster of Excellence CIBSS have demonstrated that an actin scaffold stabilizes the cell nucleus upon mechanical stress.

30 Sep 2025

Axxam and B'SYS Partner to Expand Access to Validated Ion Channel Cell Lines for High-Throughput Electrophysiology

Axxam S.p.A., a premier provider of integrated early drug discovery services, and B'SYS GmbH, a specialist in ion channel biology, are pleased to announce a strategic collaboration focused on enabling access to validated ion channel cell lines for hit and lead identification through high-throughput electrophysiological screening.

From Axxam S.p.A 8 Sep 2025

BioDlink Expands Ecosystem Alliance to Empower Biotech Innovators Worldwide

As BioDlink, a leading global CDMO, affirms its commitment to strategic alliances to support biotech innovation worldwide as it marks 15 years of operations.

From BioDlink 5 Sep 2025

RNA Binding Proteins and EVs Offer Clues to Cancer's Evasion of Immune Response

Certain types of biochemical processes can impair the immune system's ability to recognize and kill cancer cells. Purdue University's W. Andy Tao and his associates have developed a new way to study these processes.

27 Aug 2025

Parkinson’s Gene Mutation Blocks Vital Neuroprotective Signals

GBA1 mutations impair ciliary Hedgehog signaling in Parkinson's disease, reducing neuroprotective factors and highlighting a shared pathogenic pathway.

7 Aug 2025

Animal-Free 3D Fat-Immune Cell Model to Study Inflammation

Researchers developed a human adipocyte-macrophage co-culture model in GG hydrogels to study adipose tissue inflammation and test anti-inflammatory strategies.

3 Jul 2025

Chromosome Imbalance Disrupts Mitochondria Through Protein Aggregates

It has been known for several years that abnormal chromosome numbers lead to protein imbalances in the affected cells. Researchers at RPTU have now investigated the detailed effects of such imbalances.

30 Jun 2025

Exploring the Metabolic Pathways of Cancer Cells

Research from the University of Cincinnati reveals how the MYC oncogene alters PRPS enzymes, impacting redox homeostasis and lymphoma progression.

30 May 2025

Addressing Protein Leakage in Cells to Improve the Accuracy of Single-Cell Proteomic Data

A new study in Nature Communications presents a solution to protein leakage in single-cell proteomics, improving data quality by identifying and excluding permeabilized cells using a machine learning classifier.

19 May 2025

Reciprocal Regulatory Link Between ecDNA Maintenance and DNA Damage Response Revealed

Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes.

29 Apr 2025

New Drug Combo Shows Promise Against Aggressive Leukemia in Landmark Study

A novel drug combination targeting LSD1 and GSK3 shows promise in treating acute myeloid leukemia by promoting cell differentiation and reducing tumor growth.

28 Apr 2025

Hidden Causal Interaction Network Found in Cervical Cancer Cells

A Japanese research team has discovered a novel global cooperative phenomena of cell interactions in cervical cancer cells. Their findings suggest that the cells are metabolically connected in a functional network.

26 Mar 2025

Understanding How Tumor-Derived Extracellular Vesicles Enter Target Cells

Most cells in the body send out little messengers called extracellular vesicles that carry proteins, lipids, and other bioactive molecules to other cells, playing an important role in intercellular communication.

17 Mar 2025

New Microscopy Technique Reveals Cancer's Metabolic Secrets

Understanding how tumors alter their metabolism to evade treatments is an increasingly important area of cancer research.

4 Feb 2025

Random Versions of Human Genomes Created to Unlock Disease Mechanisms

The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought.

3 Feb 2025

Human Cell Lines Reveal Genome's Tolerance to Structural Variation

The most advanced engineering of human cell lines to date has been accomplished by scientists, demonstrating that genomes are more robust against significant structural changes than previously understood.

31 Jan 2025