Central Nervous System News and Research

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New Open Access Connectome Unveils Intricate Fruit Fly Neural Connections

In a first, a large, international team led by multiple labs at Harvard Medical School and Princeton University has published a complete wiring diagram of all the connections between neurons in the central nervous system of an adult fruit fly.

9 Jun 2026

Drug Boosts Axon Regrowth In Human Brain-Spinal Cord Model

This study presents a human organoid model that identifies genetic factors limiting nerve regeneration and highlights lynestrenol's role in promoting repair.

4 Jun 2026

Identifying a Genetic Switch That Halts Human Nerve Regeneration

Researchers at Cambridge have created tiny circuits in the lab that replicate the connections between the brain and spinal cord, which control human movements.

29 May 2026

Advanced Genomic Techniques Map Cellular Changes During Brain Aging

While much is mysterious about the aging process, change over time remains its cornerstone. The biological shifts that accompany aging seemingly occur in many cells in the body.

18 May 2026

Proxygen Expands Platform Beyond Degradation to Build Next-Generation Induced Proximity Therapeutics

Proxygen, a biotechnology company pioneering the discovery of molecular glue degraders and next-generation proximity-based therapeutics, today publicly announced the expansion of its platform beyond targeted protein degradation to access a broader range of induced proximity therapeutics, while advancing two lead molecular glue degrader programs toward clinical development.

From Proxygen 29 Apr 2026

New Molecular Imaging Technology Illuminates Proteins Inside Living Cells

Fluorescent probes have transformed modern biology by allowing researchers to tag and visualize individual molecules in living cells, tissues, and animals.

22 Apr 2026

Researchers Develop 3D Organoids that Reflect the Complexity of Brain Tumors

Efforts to identify and evaluate next-generation therapeutics for pediatric brain tumors are easily stymied by the quality and availability of laboratory models for research. To address this issue, scientists at St. Jude Children's Research Hospital developed patient-derived tumor organoids and tumor organoid xenografts that accurately reflect the biologic underpinnings of embryonal brain tumors.

16 Apr 2026

"Zombie" Macrophages Accumulate in Aging Tissues and Diseased Livers

UCLA researchers have identified a rogue population of immune cells that quietly accumulates in aging tissues and in the livers of people with fatty liver disease. Clearing these cells, they found, dramatically reduced inflammation and reversed liver damage in mice - even while the animals remained on an unhealthy diet.

16 Apr 2026

New Experimental System Mimics Low-Grade Pediatric Glioma in 3D

A three-dimensional experimental system has been developed to study the response to drugs in low-grade glioma, a tumor of the central nervous system that often occurs in children.

10 Apr 2026

Study Reveals How Trypanosomes Fine-Tune Protein Production Through Destruction

To survive in the human bloodstream, the African trypanosome parasite wears a "cloak" made of proteins known as a variant surface glycoprotein (VSG). The study, published in Nature Microbiology, identifies the protein that allows the parasite to fine-tune this "cloak".

31 Mar 2026

Identifying the Cellular Origin of MS-Related Neuroinflammation

Signals from the gut have been linked to autoimmune inflammation, but fundamental cellular processes remain poorly understood.

30 Mar 2026

Reversing Memory Loss in Aging Mice by Targeting Gut Bacteria

The study uncovers how gut bacteria like Parabacteroides goldsteinii contribute to memory decline, offering insights for potential cognitive interventions.

26 Mar 2026

Engineered CD4 CAR T Cells Reduce Amyloid Plaques in Alzheimer’s

Findings suggest engineered CD4+ T cells can modify Alzheimer's pathology and improve CNS immune responses, highlighting a novel therapeutic approach.

19 Feb 2026

Breakthrough Study Reveals New Line of Defense Protecting the Brain

VIB and Ghent University researchers have identified and characterized a previously unknown cellular barrier in the brain, which sheds new light on how the brain is protected from the rest of the body.

13 Feb 2026

Microglia Found to Drive New Neuron Growth in Adult Hippocampus

Breakthrough research from the University of Cincinnati College of Medicine is revealing how immune cells in the adult brain can regulate the generation of new neurons.

10 Feb 2026

Postmortem Human Retinas Recover Neural Light Signals

The ability to restore light responses in human retinas postmortem offers a novel model for studying retinal recovery and developing vision-restoring therapies.

5 Feb 2026

Why the Brain Never Stops Trying to Replace Myelin-Producing Cells

Researchers from Johns Hopkins Medicine, utilizing mouse models, reveal that oligodendrocyte precursor cells differentiate at a consistent, extensive rate throughout adulthood.

23 Jan 2026

Decoding the Molecular Logic of Histamine Signaling in the Brain

Many people are familiar with histamine, a biological molecule, that serves as a key driver of allergic reactions and other immune responses.

19 Jan 2026

Scientists Build the First Cellular Atlas of the World’s Deadliest Mosquito

The most dangerous animal in the world just got easier to study-and perhaps defeat one day.

3 Nov 2025

Golden Broccoli Aptamer Enables Real-Time Measurement of Glycine

The amino acid glycine is an important neurotransmitter that regulates memory, reflex and brain development, and it may also be a biomarker for bacterial virulence.

6 Oct 2025