Hippocampus News and Research

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The hippocampus is a part of the forebrain, located in the medial temporal lobe. It belongs to the limbic system and plays major roles in short term memory and spatial navigation. Humans and other mammals have two hippocampi, one in each side of the brain.

Genetic Signatures of Neural Progenitor Cells Uncovered in the Adult Brain

For much of the 20th century it was thought that the adult brain was incapable of regeneration. This view has since shifted dramatically and neurogenesis – the birth of new neurons – is now a widely accepted phenomenon in the adult brain, offering promising avenues for treating many neurological conditions.

22 Aug 2025

New Imaging System Reveals Cellular Activity at Unprecedented Depths

Both for research and medical purposes, researchers have spent decades pushing the limits of microscopy to produce ever deeper and sharper images of brain activity, not only in the cortex but also in regions underneath such as the hippocampus.

8 Aug 2025

Uncovering the Molecular Roots of Neural Stem Cell Decline

Age often brings a gradual decline in the ability to learn new things and retain memories. This phenomenon, often associated with the elderly, is linked to the brain's deteriorating capacity to generate new neurons-a process that primarily occurs in the hippocampus -as neural stem cells (NSCs) divide and mature.

28 Jul 2025

Memory Neurons Encoding Familiar Routes Drift with Every Experience

In a new study, Northwestern University neurobiologists found the brain's internal GPS changes each time we navigate a familiar, static environment.

24 Jul 2025

Brain Ripples Help Segment Experience Into Memories

A research team from the Faculty of Psychology at the University of Barcelona, the UB Institute of Neurosciences (UBneuro) and the Bellvitge Biomedical Research Institute (IDIBELL) has identified, for the first time in humans, and in a realistic environment, a key neurophysiological mechanism in memory formation: ripple-type brain waves -high-frequency electrical oscillations that mark and organize the different episodes or fragments of information that the brain stores as memories.

18 Jul 2025

Hippocampal Neurons Show Surprising Flexibility in Brain Signal Processing

The brain is constantly mapping the external world like a GPS, even when we don't know about it. This activity comes in the form of tiny electrical signals sents between neurons -- specialized cells that communicate with one another to help us think, move, remember and feel.

17 Jun 2025

Microscopy Study Uncovers Dynamic Brain Remodeling During Hormonal Cycles

Hormone levels fluctuate like the tides, ebbing and flowing according to carefully orchestrated cycles.

14 May 2025

Novel Therapeutic Strategy for Healthy Aging and Longevity

An international study led by the Institut de Neurociències at the UAB (INc-UAB) found that raising levels of the Klotho protein in mice extends lifespan and improves both physical and cognitive health as they age.

8 May 2025

Memories of Cold Experiences Influence Metabolism and Thermoregulation

A groundbreaking study reveals that recalling cold experiences can activate thermoregulation and metabolism in mice, suggesting memory-based interventions could help treat obesity, diabetes, and temperature-related disorders like Raynaud’s disease.

6 May 2025

AI Brings Brain Metabolism to Life in 3D with MetaVision3D

The MetaVision3D tool transforms 2D tissue sections into 3D brain metabolome models, offering critical insights into metabolism and neurological diseases.

31 Mar 2025

New Brain-Mapping Technique Pinpoints Cell Types Linked to Alzheimer's Progression

Researchers from The University of Texas at Arlington and the University of California–San Francisco have employed a novel brain-mapping technique to pinpoint memory-related brain cells that are susceptible to protein accumulation, a significant contributor to the onset of Alzheimer’s disease, an irreversible and progressive neurological disorder that gradually impairs memory and cognitive abilities.

7 Mar 2025

New Tool to Map the Origins and Journeys of Cells in Development and Disease

A new computational tool allows researchers to understand how the diverse cell types of the human body are made during development, and how diseases progress over time at the cellular level.

4 Mar 2025

New Visualization Technique Reveals Geometric Patterns in Brain Activity

Researchers at University of Tsukuba have applied a visualization technique to depict the brain's activity related to visual perception as geometric patterns.

24 Feb 2025

Targeting NMDA Receptor Subunit Shows Promise for Fragile X Syndrome

Building on more than two decades of research, a study by MIT neuroscientists at The Picower Institute for Learning and Memory reports a new way to treat pathology and symptoms of fragile X syndrome, the most common genetically-caused autism spectrum disorder.

21 Feb 2025

MARBLE Method Uncovers Shared Brain Dynamics Across Animals

In the parable of the blind men and the elephant, several blind men each describe a different part of an elephant they are touching – a sharp tusk, a flexible trunk, or a broad leg – and disagree about the animal's true nature.

18 Feb 2025

New Research Identifies Brain Cells Linked to Alcohol-Induced Insomnia

Alcohol use disorder, which affects over 10% of Americans, can lead to persistent and serious insomnia.

8 Feb 2025

Unveiling the Architecture of Native NMDA Receptors in the Mammalian Brain

A research team led by Shujia Zhu from the Chinese Academy of Sciences’ (CAS) Center for Excellence in Brain Science and Intelligence Technology and Yang Li from the Shanghai Institute of Materia Medica of CAS examined the architecture and assembly of endogenous N-methyl-ᴅ-aspartate receptors (eNMDARs) in the cerebral cortex and hippocampus of adult mammals in a study published in Cell on January 23rd, 2025.

27 Jan 2025

New Insights into the Biological Basis of Bipolar Disorder

According to research published in Nature on January 22nd, 2025, an international team of psychiatric genetics researchers has discovered 298 regions of the genome with DNA variations that increase the risk for bipolar disorder, more than four times the number previously found.

24 Jan 2025

Mapping of Neuronal IL-1R1 Expression in the Mouse Brain Sheds Light on Mood and Memory

Interleukin-1 (IL-1) is a key molecule involved in inflammation and plays an important role in both healthy and diseased states.

20 Jan 2025

Adult Neurogenesis Found to Aid Verbal Learning and Memory

Why do adults make new brain cells? A new study published in Cell Stem Cell provides the first cellular evidence that making new brain cells in adults supports verbal learning and memory, which enables people to have conversations and to remember what they hear.

6 Dec 2024