Knockout News and Research

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Dual Role of SlNOR and SlNOR-like1 Revealed in Tomato Pollen Development

Successful fertilization in flowering plants depends on healthy pollen development and structural integrity of the pollen wall.

10 Nov 2025

TRV-Mediated Gene Editing System Transforms Tomato Functional Genomics

CRISPR-Cas9 has revolutionized plant genome editing, yet its application in tomato remains limited due to the plant's recalcitrance to transformation and regeneration.

7 Nov 2025

Scientists Reveal Nonenzymatic Role of NUDT5 in Purine Pathway Regulation

Inside every cell, a finely tuned metabolic network determines when to build, recycle, or stop producing essential molecules.

7 Nov 2025

Researchers Use Bacterium’s Own Defenses to Amplify Antibiotic Power

Scientists at St. Jude Children's Research Hospital have found a way to use a bacterium's own drug resistance mechanisms against itself, presenting a potentially safer and more effective way to treat certain antibiotic-resistant infections.

3 Nov 2025

Precision Genome Editing of D3 Gene Enhances Rice Architecture and Stress Resilience

By precisely editing the D3 gene, which regulates both plant height and tillering, researchers developed compact, high-tillering rice plants that maintain grain yield while showing enhanced resistance to bacterial blight.

30 Oct 2025

RNA-Based Molecular Switch Enhances Disease Resistance in Pears

In recent years, scientists have uncovered the remarkable regulatory power of long non-coding RNAs (lncRNAs) - RNA molecules once dismissed as "genetic dark matter."

24 Oct 2025

GemPharmatech Teams Up With Memorial Sloan Kettering to Advance Antibody Innovation

GemPharmatech, a global leader in preclinical research solutions and genetically-engineered mouse models, today announced a collaboration with Memorial Sloan Kettering Cancer Center (MSK) to accelerate the discovery of new therapeutic antibodies.

24 Oct 2025

Molecular Brake SlKNU Regulates Flower Formation and Fruit Development in Tomato

Floral meristems (FMs) are small clusters of stem cells that orchestrate flower formation and ultimately determine the size and structure of the fruit.

17 Oct 2025

Research Reveals Transcriptional Mechanism Behind Salt Tolerance in Watermelon

High soil salinity disrupts water absorption, ion balance, and photosynthesis in plants, leading to growth inhibition and yield loss.

16 Oct 2025

Pioneering Approach Restores Sperm Production and Fertility in Mouse Model

For many couples facing infertility, medicine offers a range of solutions. But for men with non-obstructive azoospermia (NOA)-a genetic condition where sperm production stalls-options remain limited.

15 Oct 2025

Editing SlVI Gene Enhances Sugar Content and Disease Resistance in Tomato Fruit

Tomato fruit development relies on complex sugar metabolism, including the conversion of stored starch into sucrose, glucose, and fructose.

22 Sep 2025

Loss of Zfy Genes Explains Why Some Sperm Fail

A study at the University of Hawaiʻi at Mānoa by researchers from the John A. Burns School of Medicine (JABSOM) found that losing a crucial male fertility gene causes infertility and alters the expression of hundreds of other genes.

17 Sep 2025

Study Identifies Dcir as a Brake on Immune Responses to Aspergillus Infection

People are exposed to millions of fungal spores every day, even potentially harmful ones like those from Aspergillus fumigatus.

13 Sep 2025

Specialized Protein Structures Essential for Correct Sperm Function

There are many potential causes of infertility, and it can be challenging to pin down just what the problem is when a couple is having trouble getting pregnant.

11 Sep 2025

Parkinson’s Gene Mutation Blocks Vital Neuroprotective Signals

GBA1 mutations impair ciliary Hedgehog signaling in Parkinson's disease, reducing neuroprotective factors and highlighting a shared pathogenic pathway.

7 Aug 2025

Blocking TG2 Could Help Immune Cells Attack Ovarian Tumors

The study reveals TG2's role in ovarian cancer metastasis, suggesting that its inhibition could re-educate the immune system for better anti-tumor efficacy.

30 Jul 2025

Improved Agrobacterium Strains Enhance Plant Genetic Engineering Efficiency

These mutations improve biocontainment, transformation stability, and overall performance in genetic engineering of plants.

22 Jul 2025

VIRMA Protein Identified as Key Regulator of Ribosome Biogenesis in Brain Development

Ribosomes are tiny molecular machines inside all living cells that build proteins, and ribosome biogenesis is the complex, multi-step process by which they are made.

30 Jun 2025

Fruit Fly Study Uncovers Key Mechanisms Behind Collective Cell Migration

Researchers uncover how Plexin A and Semaphorin 1b regulate collective cell migration in fruit fly testes, offering insights into organ development, cancer metastasis, and tissue engineering.

26 Jun 2025

Histone Variant H2AZ1 Identified as Key Driver of Stem Cell Aging

Cellular senescence-a state of irreversible growth arrest accompanied by chronic inflammation-is a major contributor to aging and tissue degeneration.

18 Jun 2025