Laboratory News and Research

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Yeast-Based Platform Achieves Animal-Free High Quality Chondroitin Sulfate

By systematically redesigning multiple metabolic modules inside Komagataella phaffii, the researchers achieved both high product yield and high sulfation quality, two goals that have long been difficult to reach at the same time.

21 Jan 2026

First Fully Synthetic Bacteriophage Engineering System for Antibiotic-Resistant Bacterium

Bacteriophages have been used therapeutically to treat infectious bacterial diseases for over a century.

21 Jan 2026

Rigid Protein Molecular Rulers Enable Precise Control of Antibody Conformation

By extending a naturally rigid bacterial protein by 50% while preserving geometry and stability, the study introduces protein-based "molecular rulers" that could probe antibody shape, limit unwanted motion, and support safer, more effective antibody drug design.

21 Jan 2026

How Far-Red Light Stops Biofilms in Drug-Resistant Bacteria

Light is a fundamental signal affecting every form of life. Cycles of light and dark help set the biological clocks in organisms from unicellular bacteria to humans.

21 Jan 2026

Decoding the Molecular Logic of Histamine Signaling in the Brain

Many people are familiar with histamine, a biological molecule, that serves as a key driver of allergic reactions and other immune responses.

19 Jan 2026

Replacing Large Mouse Gene Regions with Human DNA

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes with entire human sequences has posed significant technical challenges.

19 Jan 2026

Fly Pigmentation Study Uncovers Genes Influencing Dopamine, Sleep, and Movement

Dopamine in the brain influences movement, learning, motivation and sleep. In humans, problems with dopamine are linked to conditions like Parkinson's disease, depression and sleep disorders.

14 Jan 2026

New Technique Measures How Effectively Antibiotics Kill Bacteria

Drugs that act against bacteria are mainly assessed based on how well they inhibit bacterial growth under laboratory conditions.

12 Jan 2026

Scientists Identify TRPM4 as Key Molecular Switch Controlling Intestinal Fluid Balance

Although constipation and diarrhea may seem like opposite problems, they both hinge on the same underlying issue: how much fluid moves into the gut. These common issues affect millions of people in the U.S. each year, yet scientists have not fully understood what regulates intestinal fluid balance.

12 Jan 2026

Deep Learning–Based Codon Optimization Framework Boosts Protein Expression in E. coli

By combining Transformer-based sequence modeling with a novel conditional probability strategy, the approach overcomes long-standing trade-offs between maximizing expression metrics and maintaining translational features critical for proper protein folding.

9 Jan 2026

Specialized Immune Cells Grown in Labs Offer Hope for Autoimmune Patients

Researchers at the University of British Columbia (UBC) have made a significant discovery regarding the cultivation of specialized immune cells, facilitating the development of readily available off-the-shelf cell therapies aimed at treating cancer, autoimmune diseases, and additional conditions.

9 Jan 2026

Molecular Switch Found to Control Single-Celled to Multicellular Transitions

Scientists at Nagoya University in Japan have identified the genes that allow an organism to switch between living as single cells and forming multicellular structures.

8 Jan 2026

Synthetic Biology and Metabolic Engineering Drive Microbial L-Tryptophan Biomanufacturing

This review synthesizes progress in pathway optimization, regulatory rewiring, and microbial cell factory design that has driven L-Trp titers to industrially relevant levels while enabling the biosynthesis of downstream products ranging from neurotransmitters and plant hormones to dyes and complex alkaloids.

8 Jan 2026

MD Anderson and SOPHiA GENETICS Partner to Advance AI-Driven Cancer Care

The University of Texas MD Anderson Cancer Center and SOPHiA GENETICS today announced a strategic collaboration that unites SOPHiA GENETICS' AI-powered analytics with MD Anderson's clinical and scientific expertise to accelerate data-driven cancer care through new tools that can accurately analyze, interpret and translate diagnostic results into clinical practice.

8 Jan 2026

Blocking Retinoic Acid Pathway Improves Dendritic Cell Anti-Tumor Function

Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have identified novel mechanisms by which a metabolic derivative of vitamin A-all-trans retinoic acid-compromises both the body's normal anti-cancer immune response and, in a different context, the efficacy of a promising type of cancer vaccine.

6 Jan 2026

MolGen Continues its Activities as AgriGenX

Today, we are proud to announce that MolGen’s activities will continue under the name AgriGenX.

From AgriGenX 6 Jan 2026

Study Reveals Circadian Control of Immune Variability

In laboratory models, researchers at The University of Texas MD Anderson Cancer Center discovered that a mother's circadian rhythms, or internal body clock, can influence the immune system states of her offspring, which can accurately predict the risk of bacterial infection.

5 Jan 2026