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New Aptamer Selection Strategy Streamlines Development of Safer Therapeutic Candidates

G protein-coupled receptors (GPCRs) are the most abundantly expressed proteins in the human body, which regulate diverse physiological processes ranging from pain perception to hormone signaling.

8 Jul 2026

New Research Maps Gut Microbiome Impact on Liver Cancer Immunotherapy Resistance

Immune checkpoint blockade (ICB) has reshaped the treatment landscape for advanced hepatocellular carcinoma (HCC), offering new hope where few options existed.

3 Jul 2026

Cancer Cells Hijack Macrophage Metabolism to Create an Immunosuppressive Tumor Microenvironment

Tumor-associated macrophages (TAMs) are among the most abundant immune cells in the tumor microenvironment. However, instead of attacking cancer cells, they are typically co-opted to support tumor growth, metastasis, and therapeutic resistance.

2 Jul 2026

Scientists Decode 3D Structure of Vision Proteins to Fight Blindness

They allow us to see the world in thousands of colors: red strawberries, green leaves, the blue sky.

26 Jun 2026

Researchers Outline Dynamic Protein Control Systems for Better Clinical Decisions

Cancer has often been explained through mutations in deoxyribonucleic acid (DNA) or changes in ribonucleic acid (RNA), but these layers do not fully explain why tumors with similar genetic profiles can behave differently.

10 Jun 2026

Study Provides Surprising Insights Into Special Brain Receptor Complex

Nerve cells in the brain use chemical messengers for communication.

9 Jun 2026

Synthetic Biology and Artificial Intelligence Transform the Discovery of Mysterious Orphan Receptors

A new review highlights how synthetic biology, AI, and spatial omics could transform ligand-receptor discovery from one-by-one searches into network-level mapping

23 May 2026

Molecular Keyhole Discovery Unlocks New Target for Pain Therapies

Researchers at VIB, VUB, and KU Leuven have identified a tiny binding site, a molecular 'keyhole', in the TRPM3 ion channel, a crucial sensor in pain signaling.

22 Apr 2026

MIT Chemists Discover How Membrane Lipids Drive Uncontrolled Cancer Cell Growth

Cells are enveloped by a lipid membrane that gives them structure and provides a barrier between the cell and its environment. However, evidence has recently emerged suggesting that these membranes do more than simply provide protection - they also influence the behavior of the protein receptors embedded in them.

17 Apr 2026

New AI Tool Guides Chemists Toward Faster Drug Discovery

Drug discovery is like molecular Tetris. Chemists snap atoms together, adjusting the pieces until everything fits and suddenly, a molecule makes a promising new medicine.

10 Mar 2026

Promega Unveils Cellular Target Engagement Technology Aimed at Expanding the Druggable Proteome at SLAS 2026

Promega Corporation is launching a new live-cell target engagement platform that could close a long-standing gap between biochemical and cellular assays for understudied or difficult-to-interrogate proteins.

27 Feb 2026

Mapping the Binding Energy of Histamine Receptors

G-protein-coupled receptors (GPCRs) are one of the biggest groups of cell surface proteins in the human body, recognizing hormones, neurotransmitters, and drugs.

16 Feb 2026

Bone-building hormone eases chronic low back pain by restoring vertebral microarchitecture

Parathyroid hormone shows promise in treating low back pain by remodeling degenerating vertebral endplates and limiting pathological sensory innervation.

12 Feb 2026

Single-cell atlas reveals how melanoma evades the immune system

Integrative analysis of immune ecotypes in skin cancers highlights metabolic reprogramming and macrophage polarization as key factors in melanoma progression.

11 Feb 2026

Blood protein test helps spot hidden cancers in patients with vague symptoms

Plasma protein profiling offers a promising tool for cancer risk stratification in patients with non-specific symptoms, potentially reducing diagnostic delays.

28 Jan 2026

Engineered Human Skin Acts as a Living Biosensor for Inflammation

Implanted living skin-based biosensors offer a breakthrough in inflammation tracking, providing real-time biomarker monitoring without invasive procedures.

21 Jan 2026

Decoding the Molecular Logic of Histamine Signaling in the Brain

Many people are familiar with histamine, a biological molecule, that serves as a key driver of allergic reactions and other immune responses.

19 Jan 2026

Unusual Antibody Tactics Hinder Pathogen Attachment to Cells

Pathogens can create sticky situations. When microbes invade the body to cause an infection, often one of their first lines of attack is to cling tenaciously to the surfaces of targeted human cells.

8 Jan 2026

Innovative mRNA Technology Rejuvenates Aging Immune System in Mice

Can the weakened immune systems of older individuals be rejuvenated? Researchers from the German Cancer Research Center (DKFZ), the HI-STEM institute, and the Broad Institute have demonstrated that this is possible with an innovative approach.

18 Dec 2025

St. Jude Scientists Discover Hidden Binding Pocket in Nuclear Receptors

A study from St. Jude Children's Research Hospital uncovered an alternative binding pocket within nuclear receptors, revealing a much-needed new therapy route for this important class of drug targets.

7 Nov 2025