Biochemistry

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Study reveals mechanism by which ibuprofen prevents RAC1B alternative splicing in colorectal cells

Oncotarget published "Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells" which reported that although the molecular mechanism behind the antitumor properties of NSAIDs has been largely attributed to inhibition of cyclooxygenases , several studies have shown that the chemopreventive properties of ibuprofen also involve multiple COX-independent effects.

23 Mar 2021

Study maps structure, mechanism of membrane enzyme that has a role in chronic inflammation, cancer

A majority of the drugs work through the membranes surrounding the cells of the body.

22 Mar 2021

Immune receptor proteins can help treat autoimmune diseases

TARM1 is a receptor protein, whose function in the working of the immune system is not known yet. Now, in a new research work, Japanese researchers have analyzed mouse models to investigate the promising role of TARM1 protein in the pathogenesis of rheumatoid arthritis.

From Tokyo University of Science 18 Mar 2021

Study shows beneficial effects of gene therapy can be observed even after several decades

A new study shows that the advantageous effects of gene therapy can be observed several decades after the body clears the transplanted blood stem cells.

From University College London 18 Mar 2021

Study provides clues for designing more effective antiviral drugs

An international research team from the University of Turku based in Finland and PennState University based in the United States has solved an ancient puzzle of how living organisms differentiate between DNA and RNA building blocks at the time of gene expression, offering new possibilities for designing novel antiviral medications.

18 Mar 2021

Researchers identify address codes in odorant receptor proteins for the first time

A team of scientists led by Dietmar Krautwurst from the Leibniz Institute for Food Systems Biology at the Technical University of Munich has now identified address codes in odorant receptor proteins for the first time.

18 Mar 2021

Researchers develop new cell-based test system to identify immunoregulatory modulators

Our immune system is very successful when it comes to warding off viruses and bacteria. It also recognizes cancer cells as potential enemies and fights them. However, cancer cells have developed strategies to evade surveillance by the immune system and to prevent immune response.

18 Mar 2021

New machine learning method detects the pH of a cell to identify whether it is cancerous

Cancerous cells differ from healthy cells in various significant ways. This helps identify them as harmful.

17 Mar 2021

Lowering apolipoprotein CIII levels can prevent deleterious effects of a high-fat diet

Consumption of a diet with high fat levels increases the risk of fatty liver, obesity, cardiovascular diseases, and type 2 diabetes.

15 Mar 2021

Scientists reveal how critical enzyme in the cell works

S-acylation is the process of chemically linking a lipid to protein via a thioester bond. It is an important process of the cell that regulates the localization and function of numerous proteins.

12 Mar 2021

New method to lower the cost of carbon capture

As part of a marathon research effort to lower the cost of carbon capture, chemists have now demonstrated a method to seize carbon dioxide (CO2) that reduces costs by 19 percent compared to current commercial technology.

12 Mar 2021

Spraying leaves with vitamin C can dramatically increase protein production

The production of high-value pharmaceutical proteins in plants provides benefits over other manufacturing techniques.

10 Mar 2021

RNA-editing events can reveal the genetic basis of many human diseases

Scientists from CHOP have detected RNA-editing events that affect the expression of genes and the phenotypic manifestation of that specific expression.

10 Mar 2021

Volatile signal in plants activates defense and inhibits growth processes

An international research team has performed a new study that revealed that Arabidopsis thaliana plants create beta-cyclocitral when attacked by herbivores.

10 Mar 2021

Probiotic spray reduced incidence of fire blight in apple flowers

While many celebrate apple blossoms as classic signs of spring, they are also welcoming entry gates for pathogens. Full of nutrients to lure pollinators and promote pollen germination, flowers also attract bacteria like Erwinia amylavora, a pathogen that causes a damaging disease called fire blight.

10 Mar 2021

PrecisionTox aims to protect human health from the toxic effects of chemicals

A major research project to shape regulation and policy on chemical safety without the use of animal testing has been launched with the aid of €19.3M funding from the European Commission.

10 Mar 2021

New drug target identified for antibiotic-resistant bacteria

Scientists have discovered a key mechanism that enables dangerous bacteria to develop resistance to antibiotics.

9 Mar 2021

New infrared microscope helps image biological samples at the microscopic level

Scientists have designed a new spectroscopic microscope to optically measure the orientations and conformations of molecules in biological specimens.

9 Mar 2021

New substance could improve the treatment of drug-resistant cancers

A new substance could improve the treatment of persistent cancers. Researchers at Martin Luther University Halle-Wittenberg and the University of Greifswald have developed a new inhibitor that makes drug-resistant tumor cells respond again to chemotherapy.

9 Mar 2021

Psychoactive component of marijuana stays in breast milk for up to six weeks, study finds

In a new study published in JAMA Pediatrics, researchers at Children's Hospital Colorado have found that tetrahydrocannabinol (THC), the psychoactive component of marijuana, stays in breast milk for up to six weeks, further supporting the recommendations of the American Academy of Pediatrics, the American College of Obstetricians and Gynecologists and the Academy of Breastfeeding Medicine to abstain from marijuana use during pregnancy and while a mother is breastfeeding.

9 Mar 2021

Biochemistry

Study reveals mechanism by which ibuprofen prevents RAC1B alternative splicing in colorectal cells

Study maps structure, mechanism of membrane enzyme that has a role in chronic inflammation, cancer

Immune receptor proteins can help treat autoimmune diseases

Study shows beneficial effects of gene therapy can be observed even after several decades

Study provides clues for designing more effective antiviral drugs

Researchers identify address codes in odorant receptor proteins for the first time

Researchers develop new cell-based test system to identify immunoregulatory modulators

New machine learning method detects the pH of a cell to identify whether it is cancerous

Lowering apolipoprotein CIII levels can prevent deleterious effects of a high-fat diet

Scientists reveal how critical enzyme in the cell works

New method to lower the cost of carbon capture

Spraying leaves with vitamin C can dramatically increase protein production

RNA-editing events can reveal the genetic basis of many human diseases

Volatile signal in plants activates defense and inhibits growth processes

Probiotic spray reduced incidence of fire blight in apple flowers

PrecisionTox aims to protect human health from the toxic effects of chemicals

New drug target identified for antibiotic-resistant bacteria

New infrared microscope helps image biological samples at the microscopic level

New substance could improve the treatment of drug-resistant cancers

Psychoactive component of marijuana stays in breast milk for up to six weeks, study finds

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