Cell Biology

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Parkinson’s Gene Mutation Blocks Vital Neuroprotective Signals

GBA1 mutations impair ciliary Hedgehog signaling in Parkinson's disease, reducing neuroprotective factors and highlighting a shared pathogenic pathway.

7 Aug 2025

Magnetic Microneedle Robots Transform Tissue Slicing and Cultivation

In a pioneering development for the biomedical field, a research team led by Yuanjin Zhao from Nanjing Drum Tower Hospital, China, has published a research article in Engineering.

6 Aug 2025

Ribosome Levels Drop During Early Brain Development

A team led by UT Southwestern Medical Center scientists has identified a specific stage of neurodevelopment when differentiating neural cells produce fewer ribosomes, which are responsible for making proteins.

6 Aug 2025

Uncovering How Cells Precisely Control Protein Production

It's known as biology's central dogma: All living organisms' genetic information is stored in DNA, which is transcribed into RNA, which is translated into proteins that perform nearly all essential tasks in a cell.

6 Aug 2025

New Computational Tool Reveals How Long Non-Coding RNAs Control Gene Expression

Long non-coding RNAs (lncRNA) are a type of RNA molecule that do not carry instructions to make proteins. Instead, they influence how other genes are expressed.

6 Aug 2025

Case Western Researchers Use Stem Cells to “Shut Off” Nerve Cell Strain

Amyotrophic lateral sclerosis (ALS), sometimes known as Lou Gehrig’s disease, is an incurable neurological disease that affects motor neurons, which are nerve cells in the brain and spinal cord that regulate voluntary muscle movement and breathing.

6 Aug 2025

Prime Editing Reverses Symptoms of Severe Childhood Neurological Disease

Scientists use a precise form of gene editing called prime editing to correct the most common genetic mutations that cause alternating hemiplegia of childhood, a rare and severe neurological disorder that begins in infancy.

From The Jackson Labs 6 Aug 2025

CD276 Antibody Strategy Offers Hope For Immune-Resistant Lung Tumors

The study highlights 8H8_SDIE's role in activating NK cells against NSCLC, offering a new strategy for patients resistant to conventional immunotherapies.

6 Aug 2025

UCLA Researchers Reprogram Stem Cells to Produce Continuous Cancer-Fighting T Cells

In a first-of-its-kind clinical trial, UCLA scientists have shown it's possible to reprogram a patient's blood-forming stem cells to generate a continuous supply of functional T cells, the immune system's most powerful cancer-killing agents.

5 Aug 2025

Scientists Uncover New Activation Mechanism of the Human Sweet Taste Receptor

Sweet taste receptors are proteins in taste buds that detect sugar and other sweeteners, but the mechanism underlying how they elicit a sweet response has been unclear.

5 Aug 2025

Research Reveals How Gut Bacteria Interact to Maintain Intestinal Balance

Intestinal bacteria are important for human health as they help digest food and regulate immune function.

4 Aug 2025

AI-Powered Protein Design Opens Doors to New T-Cell Based Immunotherapies

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key driver in T-cell development and function.

4 Aug 2025

New Insights Reveal How Cell Membranes Follow Unified Biophysical Laws

Cell membranes cradle, protect, and gatekeep living cells. Membranes can even affect how a cell behaves.

4 Aug 2025

Mitochondrial Gene Found to Regulate Wood Formation in Poplar

Mitochondria are widely known as the "powerhouses" of the cell, generating the energy needed for life. But in plants, their role goes far beyond metabolism.

31 Jul 2025

Cancer Cells Trigger Instant Energy Surge When Squeezed

Cancer cells mount an instant, energy‑rich response to being physically squeezed, according to a study published in the journal Nature Communications.

31 Jul 2025

Thalamus Found to Modulate Cortical Sensitivity to Touch

The cerebral cortex processes sensory information via a complex network of neural connections. How are these signals modulated to refine perception? A team from the University of Geneva (UNIGE) has identified a mechanism by which certain thalamic projections target neurons and modify their excitability.

31 Jul 2025

PD-1 Guides T Cells to Become Long-Term Immune Defenders in the Skin

Weill Cornell Medicine researchers have discovered that PD-1—a molecule best known for putting the brakes on immune cells—also plays a critical role in helping T cells become long-term immune defenders in the skin.

30 Jul 2025

Blocking TG2 Could Help Immune Cells Attack Ovarian Tumors

The study reveals TG2's role in ovarian cancer metastasis, suggesting that its inhibition could re-educate the immune system for better anti-tumor efficacy.

30 Jul 2025

Discovery of New Mitophagy Trigger Offers Hope for Parkinson’s Disease

Autophagy is essentially the 'rubbish collection' of our cells. If there are problems in this process, which is so important for our health, diseases such as Parkinson's can result. In their latest study, leading cell biologists at the Max Perutz Labs at the University of Vienna investigated mitophagy – a form of autophagy – and came to a remarkable conclusion: the researchers have described a new trigger for mitophagy.

29 Jul 2025

Injectable Hydrogels Use Milk-Derived Vesicles to Promote Tissue Regeneration

Researchers from Columbia Engineering have established a framework for the design of bioactive injectable hydrogels formulated with extracellular vesicles (EVs) for tissue engineering and regenerative medicine applications.

29 Jul 2025