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Promising Drug Offers Hope for Overcoming Resistance to Protein Degraders

Protein degraders, a novel approach in drug discovery, show promise to tackle diseases previously thought to be untreatable.

31 Jan 2024

Gene Therapy Can Interrupt the Progression of Deadly Inherited Heart Condition

A new study in mice shows that replacement of a dysfunctional gene could prolong survival in some people with arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare inherited disorder in which the muscular walls of the heart progressively weaken and put patients at risk of dangerous irregular heartbeats.

31 Jan 2024

Scientists Unleash the Power of Calcium to Target and Destroy Tumor Cells

Calcium ions are essential for cells, but can be toxic in higher concentrations. A team of researchers has now designed and prepared a combination drug that kills tumor cells by modulating the calcium influx into the cell.

30 Jan 2024

Study Shows How Obesity Causes Mitochondrial Fragmentation in Fat Cells

The number of people with obesity has nearly tripled since 1975, resulting in a worldwide epidemic.

30 Jan 2024

Traffic Jam in the Brain: Study Uncovers Cellular Cause of Rare Neurological Disease

Researchers from McGill University, led by Professor Alanna Watt of the Department of Biology, have identified previously unknown changes in brain cells affected by a neurological disease.

22 Jan 2024

Understanding How Inherited DNA Variations Influence Blood Cancer Development

Large-scale genetic analysis has helped researchers uncover the interplay between cancer-driving genetic mutations and inherited genetic variants in a rare type of blood cancer.

18 Jan 2024

Genome-Wide Study Identifies Gene Pair Crucial for Regulating Blood Vessel Disease in the Lungs

University of Pittsburgh Schools of Medicine researchers uncovered a fundamental mechanism that controls the body's response to limited oxygen and regulates blood vessel disease of the lung.

16 Jan 2024

Mosaic Turner Syndrome Identified in 2500-Year-Old Briton: Ancient DNA Reveals Hidden History

Researchers at the Francis Crick Institute, working with University of Oxford, University of York and Oxford Archaeology, have developed a new technique to measure the number of chromosomes in ancient genomes more precisely, using it to identify the first prehistoric person with mosaic Turner syndrome (characterized by one X chromosome instead of two [XX]), who lived about 2500 years ago.

16 Jan 2024

Breakthrough 3D Vascular Sheet Mimics Atherosclerosis for High-Throughput Drug Screening

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

16 Jan 2024

EBV-Targeting T-Cells Linked to Early MS Damage

The body's immune response to Epstein-Barr virus (EBV) may play a role in causing damage in people with multiple sclerosis, according to a new study led by UTHealth Houston.

12 Jan 2024

Boosting Post-Transplant Survival: Tailoring Gut Microbiome to Fight GvHD

After stem cell transplantation, the donated immune cells sometimes attack the patients' bodies. This is known as graft versus host disease or GvHD.

9 Jan 2024

Novel Amino Acid Nanoparticles Offer Hope for Fighting Multi-Drug Resistant Cancers

Amino acids, such as tyrosine and tryptophan, are the fundamental building blocks that make up proteins.

9 Jan 2024

Scientists Develop Tiny Human Cerebellums to Decipher Disease and Design Therapies

In a first for USC Stem Cell scientists, the laboratory of Giorgia Quadrato, an assistant professor of stem cell biology and regenerative medicine, has pioneered a novel human brain organoid model that generates all the major cell types of the cerebellum, a hindbrain region predominantly made up of two cell types necessary for movement, cognition, and emotion: granule cells and Purkinje neurons.

5 Jan 2024

Genetic Twist in Tiny Protein Protects Against Parkinson's

A previously unidentified genetic mutation in a small protein provides significant protection against Parkinson's disease and offers a new direction for exploring potential treatments, according to a new USC Leonard Davis School of Gerontology study.

3 Jan 2024

AI Tool Offers a Deep Dive Into Tissues, Boosting Cancer Detection and Treatment

A new artificial intelligence tool that interprets medical images with unprecedented clarity does so in a way that could allow time-strapped clinicians to dedicate their attention to critical aspects of disease diagnosis and image interpretation.

3 Jan 2024

AI-Powered Drug Breakthrough: Insilico Unveils Potent FGFR2/3 Inhibitor for Solid Tumors

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

29 Dec 2023

Hyperglycemia Impairs Mitochondrial Function and Survival of Human Adipose Tissue-Derived MSCs

Mesenchymal stem cells (MSCs) are a type of stem cells that possess relevant regenerative abilities and can be used to treat many chronic diseases.

27 Dec 2023

Study Reveals Tissue-Specific Effects of JAK1 Signaling in Inflammation

Researchers at the Icahn School of Medicine at Mount Sinai have gained a deeper understanding of the nuanced roles of JAK inhibitors, or modulators, in inflammation across various cell types and tissues.

26 Dec 2023

Scientists Unravel the Mystery of Parkinson's Disease With 3D Protein Structures

Scientists at St. Jude Children's Research Hospital revealed the complex structure of two Parkinson's disease-related proteins, both of which are implicated in late-onset cases.

26 Dec 2023

The Adrenaline Puzzle Solved: Scientists Untangle Key Cell Receptor's Inner Workings

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.

26 Dec 2023

Medical Condition News

Promising Drug Offers Hope for Overcoming Resistance to Protein Degraders

Gene Therapy Can Interrupt the Progression of Deadly Inherited Heart Condition

Scientists Unleash the Power of Calcium to Target and Destroy Tumor Cells

Study Shows How Obesity Causes Mitochondrial Fragmentation in Fat Cells

Traffic Jam in the Brain: Study Uncovers Cellular Cause of Rare Neurological Disease

Understanding How Inherited DNA Variations Influence Blood Cancer Development

Genome-Wide Study Identifies Gene Pair Crucial for Regulating Blood Vessel Disease in the Lungs

Mosaic Turner Syndrome Identified in 2500-Year-Old Briton: Ancient DNA Reveals Hidden History

Breakthrough 3D Vascular Sheet Mimics Atherosclerosis for High-Throughput Drug Screening

EBV-Targeting T-Cells Linked to Early MS Damage

Boosting Post-Transplant Survival: Tailoring Gut Microbiome to Fight GvHD

Novel Amino Acid Nanoparticles Offer Hope for Fighting Multi-Drug Resistant Cancers

Scientists Develop Tiny Human Cerebellums to Decipher Disease and Design Therapies

Genetic Twist in Tiny Protein Protects Against Parkinson's

AI Tool Offers a Deep Dive Into Tissues, Boosting Cancer Detection and Treatment

AI-Powered Drug Breakthrough: Insilico Unveils Potent FGFR2/3 Inhibitor for Solid Tumors

Hyperglycemia Impairs Mitochondrial Function and Survival of Human Adipose Tissue-Derived MSCs

Study Reveals Tissue-Specific Effects of JAK1 Signaling in Inflammation

Scientists Unravel the Mystery of Parkinson's Disease With 3D Protein Structures

The Adrenaline Puzzle Solved: Scientists Untangle Key Cell Receptor's Inner Workings

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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