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Study reveals genetically driven mucus pathobiology in asthma

A significant amount of genetic risk for asthma is likely mediated through altered gene expression within the airway epithelium.

29 Mar 2022

CDH17CAR T cells can eliminate solid tumors without damaging healthy tissues

Chimeric antigen receptor (CAR) T cells can be remarkably effective in treating leukemias and lymphomas, but there are no successful immunotherapies for neuroendocrine tumors (NETs) and gastrointestinal cancers (GICs) yet.

25 Mar 2022

Gene mutation influences autism development, study finds

A research team discovered that interruption of a circadian clock gene may be implicated in the formation of autism spectrum disorder.

25 Mar 2022

Scientists develop a new computational biology method to better understand IBD

Around 500,000 people in the UK live with Inflammatory Bowel Disease (IBD), a life-long, chronic condition characterized by sporadic bouts of gut inflammation causing debilitating symptoms.

15 Mar 2022

Researchers create a mobile app to calculate genetic risk for coronary artery disease

A Scripps Research team developed a smartphone app that can calculate users' genetic risk for coronary artery disease (CAD)-; and found that users at high risk sought out appropriate medication after using the app.

15 Mar 2022

Genetic rat model shows robust Down syndrome features

In pursuit of better ways to test new therapies and further explore the impacts of the unique genetics associated with Down syndrome, researchers at Johns Hopkins Medicine and Tottori University in Japan have genetically engineered and characterized what is believed to be the first rat model of Down syndrome.

15 Mar 2022

Cellular therapy leads to meaningful functional improvements in DMD patients

A clinical trial at UC Davis Health and six other sites showed that a cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy (DMD), a rare genetic disorder causing muscle loss and physical impairments in young people.

From The University of California, Davis 14 Mar 2022

Yale researchers find a way to 'supercharge' tumor-attacking T cells

Yale scientists have identified a way to "supercharge" tumor-attacking T cells, a finding that may not only improve the effectiveness of a promising type of cell-based cancer immunotherapy but also expand the number of cancers it can treat.

11 Mar 2022

Researchers identify the underlying molecular mechanism for development of chronic pain

One epigenetic factor as well as one organic anion transporter (OAT1), whose function in the nervous system was hitherto unknown, contribute to the development of chronic pain.

9 Mar 2022

Study takes a deep dive into the molecular biology of the brain in bipolar disorder patients

In a comprehensive study involving one of the largest-ever samples of post-mortem brains, scientists at the Lieber Institute for Brain Development, in collaboration with researchers at the Johns Hopkins School of Medicine and Bloomberg School of Public Health, have pinpointed significant differences in gene expression in two specific regions of the brains of hundreds of patients who had bipolar disorder.

8 Mar 2022

Specific gene variant linked with poor response to sublingual immunotherapy for allergies

Although sublingual immunotherapy (SLIT) has become an effective treatment option for many allergies, about 20-30% of patients don’t respond to SLIT for Japanese cedar pollinosis–a highly common disease.

8 Mar 2022

UTSA team develops innovative inhibitor to fight obesity and heart disease

An interdisciplinary research team at The University of Texas at San Antonio has successfully developed an innovative inhibitor that shows promise in fighting obesity and potentially preventing heart disease.

4 Mar 2022

Two distinct classes of stem cells drive treatment resistance in patients with myelodysplastic syndromes

Researchers from The University of Texas MD Anderson Cancer Center discovered that treatment resistance in patients with myelodysplastic syndromes (MDS) is caused by two distinct classes of stem cells and identified possible therapeutic approaches that target these cells.

3 Mar 2022

UH researcher secures $2 million to develop drugs for formerly undruggable cancer targets

With a $2 million recruitment grant from the Cancer Prevention and Research Institute of Texas, a University of Houston researcher is setting up a lab to develop drugs that will work on traditionally undruggable targets in cancer.

3 Mar 2022

Study uncovers genomic drivers and therapeutic vulnerabilities of transformed cutaneous T-cell lymphoma

Cutaneous T-cell lymphoma (CTCL) is an incurable, rare cancer of skin-homing T cells that is highly disfiguring and lethal at advanced stages.

2 Mar 2022

Protein appears key to the function and survival of brain cells most impacted by glaucoma

A ubiquitous protein called sigma 1 receptor, which is known to protect cells from stress, appears key to the function and survival of the neurons most impacted by glaucoma, scientists report.

2 Mar 2022

Novel molecular pathway shared by ALS and frontotemporal dementia identified

Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia.

1 Mar 2022

US research reveals the role of Heparan Sulfate in obesity

AMSBIO reports how researchers at the Washington University School of Medicine (St. Louis, USA) have used their 10E4 Heparan Sulfate (HS) antibody in pioneering obesity research to quantify the role of HS in the process of intercellular mitochondria transfer to macrophages.

From AMS Biotechnology 1 Mar 2022

Looking at protein activity gives a complete picture of leukemia's weaknesses

Blocking a protein chain reaction makes childhood leukemia cells more sensitive to an existing targeted treatment, a new study shows.

28 Feb 2022

Scientists elucidate mechanism that causes treatment resistance in aggressive pancreatic cancer

Drug resistance is a major obstacle in the treatment of cancers. In an aggressive type of pancreatic cancer, for instance, drug resistance is associated with the suppression of programmed cell death, which results in the uncontrolled growth of cancer cells.

25 Feb 2022

Medical Condition News

Study reveals genetically driven mucus pathobiology in asthma

CDH17CAR T cells can eliminate solid tumors without damaging healthy tissues

Gene mutation influences autism development, study finds

Scientists develop a new computational biology method to better understand IBD

Researchers create a mobile app to calculate genetic risk for coronary artery disease

Genetic rat model shows robust Down syndrome features

Cellular therapy leads to meaningful functional improvements in DMD patients

Yale researchers find a way to 'supercharge' tumor-attacking T cells

Researchers identify the underlying molecular mechanism for development of chronic pain

Study takes a deep dive into the molecular biology of the brain in bipolar disorder patients

Specific gene variant linked with poor response to sublingual immunotherapy for allergies

UTSA team develops innovative inhibitor to fight obesity and heart disease

Two distinct classes of stem cells drive treatment resistance in patients with myelodysplastic syndromes

UH researcher secures $2 million to develop drugs for formerly undruggable cancer targets

Study uncovers genomic drivers and therapeutic vulnerabilities of transformed cutaneous T-cell lymphoma

Protein appears key to the function and survival of brain cells most impacted by glaucoma

Novel molecular pathway shared by ALS and frontotemporal dementia identified

US research reveals the role of Heparan Sulfate in obesity

Looking at protein activity gives a complete picture of leukemia's weaknesses

Scientists elucidate mechanism that causes treatment resistance in aggressive pancreatic cancer

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