Molecular & Structural Biology

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Global Ocean Microbiome Catalogue Opens New Frontiers In Marine Bioprospecting

Recent advancements in sequencing have led to the GOMC, a comprehensive catalog of marine microbiomes, enhancing prospects for biotechnological applications.

12 Sep 2024

Genetic Blueprint of Atractylodes Lancea Reveals Key Insights for Medicinal Use

Scientists have decoded the genetic blueprint of Atractylodes lancea, a prized herb in traditional Chinese medicine.

12 Sep 2024

Ribose-Water Interactions Stabilize RNA Structures

Ribonucleic acid (RNA) is a biological molecule that plays an important part in organismal genetics as well as the creation and development of life.

11 Sep 2024

A New Approach to Engineering Complex Organoids

A novel molecular engineering technology can precisely control the formation of organoids. Microbeads composed of precisely folded DNA are utilized to deliver growth factors or other signal molecules into tissue structures.

11 Sep 2024

New Insights into RNA Export Mechanisms in Drosophila Revealed

Eukaryotic cells are complex biological units, each with multiple membrane-bound compartments. These cells use specialized mechanisms to export biomolecules from their synthesis site to where they function.

10 Sep 2024

Crystal Structure of i-Motif DNA Opens Doors for Targeted Drug Design

The first crystal structure of an alternative DNA shape from the insulin gene has been revealed by a UCL-led research team.

9 Sep 2024

New Advances in DEL Technology Facilitate Synthesis of Large, Complex Molecules

These days, remarkable new medical treatments are all the rage. One such treatment is personalized cancer therapy, which uses antibodies or immune cells that have been altered.

4 Sep 2024

Alternative Splicing Shapes Biological Complexity through Gene Expression Modulation

A genetic process known as “alternative splicing” involves cutting out specific gene segments and joining the remaining segments to form messenger RNA (mRNA) during transcription.

4 Sep 2024

Single-Cell Sequencing Reveals Mechanism of Coronary Artery Formation

The process by which new arteries develop in the heart has been clarified by a group under the direction of Dr. Elena Cano at the Integrative Vascular Biology Lab of Professor Holger Gerhardt at the Max Delbrück Center in Berlin.

2 Sep 2024

The Molecular Process That Causes MS and Autoimmune Diseases

A human immune system suppressor known as “regulatory T cells” was first identified more than 20 years ago by a research team working in the lab of Yale researcher David Hafler, who was at Harvard at the time.

29 Aug 2024

High-Speed Atomic Force Microscopy Reveals Cofilin Binding Patterns in Actin Filaments

Researchers at Kanazawa University report in eLife on deciphering the actin structure-dependent preferential cooperative binding of cofilin.

29 Aug 2024

Single-Cell RNA Sequencing Reveals Cellular Changes in Early Alzheimer's Disease

An analysis of more than 1.6 million brain cells from older adults has captured the cellular changes that occur in the early stages of Alzheimer's disease, potentially revealing new routes for preventing the most common cause of dementia in older individuals.

29 Aug 2024

Sae2 Regulates Critical DNA Repair Functions in Yeast

DNA damage is a cellular phenomenon that introduces structural abnormalities in double-stranded DNA. External factors, such as radiation or chemical agents, as well as internal factors, such as blocked DNA replication, can generate double-strand breaks (DSBs) in DNA.

29 Aug 2024

Nutrient Deprivation Strategy Kills Breast Cancer Cells by Blocking Adaptive Pathways

Cancer cells have voracious appetites. And there are certain nutrients they can't live without. Scientists have long hoped they might stop tumors in their tracks by cutting off an essential part of cancer cells' diet. But these cells are crafty and often find a new way to get what they need. How? By reprogramming their metabolism and switching to backup food supplies.

29 Aug 2024

New Map Reveals Hidden Interactions Between Receptors and Proteins

A single superfamily of receptors found on the surface of human cells is the target of one out of every three FDA-approved medications.

28 Aug 2024

CDCA7's Role in DNA Methylation Maintenance Revealed in Recent Study

DNA methylation is a process in which a methyl group is attached to the cytosine base of the DNA molecule, and a major way that DNA is epigenetically marked. Epigenetic modifications can act as on-off switches to regulate gene expression and help generate diverse cell types without changing the underlying DNA sequence. It is how the body ensures that brain-related genes don't get turned on in heart cells, for example.

28 Aug 2024

EMBL Researchers Develop Novel Photoacoustic Probes to Monitor Brain Activity

To understand the brain better, we need new methods to observe its activity.

28 Aug 2024

High-Resolution Structures Illuminate the Chloroplast Protein Import Machinery in Plants

Two groundbreaking studies published in the journal Cell shed light on the assembly, function and evolutionary diversity of the chloroplast protein import system.

28 Aug 2024

Unraveling the Molecular Mechanism Behind Neocapritermes taracua's Explosive Defense

Researchers from the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, in cooperation with colleagues from the Faculty of Tropical AgriScience of the Czech University of Life Sciences in Prague, are unraveling the mysteries of the life of termites.

28 Aug 2024

Insights into Hmmr's Role in Cognitive Decline and Lifespan

The authors investigate the physiological functions of Terc-53 by creating transgenic mice that overexpress this noncoding RNA. They observe that Terc-53 overexpression affects normal aging in mammals, contributing to cognitive decline and shortened lifespan.

27 Aug 2024

Molecular & Structural Biology

Global Ocean Microbiome Catalogue Opens New Frontiers In Marine Bioprospecting

Genetic Blueprint of Atractylodes Lancea Reveals Key Insights for Medicinal Use

Ribose-Water Interactions Stabilize RNA Structures

A New Approach to Engineering Complex Organoids

New Insights into RNA Export Mechanisms in Drosophila Revealed

Crystal Structure of i-Motif DNA Opens Doors for Targeted Drug Design

New Advances in DEL Technology Facilitate Synthesis of Large, Complex Molecules

Alternative Splicing Shapes Biological Complexity through Gene Expression Modulation

Single-Cell Sequencing Reveals Mechanism of Coronary Artery Formation

The Molecular Process That Causes MS and Autoimmune Diseases

High-Speed Atomic Force Microscopy Reveals Cofilin Binding Patterns in Actin Filaments

Single-Cell RNA Sequencing Reveals Cellular Changes in Early Alzheimer's Disease

Sae2 Regulates Critical DNA Repair Functions in Yeast

Nutrient Deprivation Strategy Kills Breast Cancer Cells by Blocking Adaptive Pathways

New Map Reveals Hidden Interactions Between Receptors and Proteins

CDCA7's Role in DNA Methylation Maintenance Revealed in Recent Study

EMBL Researchers Develop Novel Photoacoustic Probes to Monitor Brain Activity

High-Resolution Structures Illuminate the Chloroplast Protein Import Machinery in Plants

Unraveling the Molecular Mechanism Behind Neocapritermes taracua's Explosive Defense

Insights into Hmmr's Role in Cognitive Decline and Lifespan

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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