Molecular & Structural Biology

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Functions of gamma delta T cells are regulated by sugars and fat Gene, shows study

The team led by Bruno Silva Santos, Principal Investigator and Deputy Director of the Instituto de Medicina Molecular João Lobo Antunes (iMM) and Professor at the Faculdade de Medicina da Universidade de Lisboa, discovered that the functions of a subtype of white blood cells - gamma delta T cells - are regulated by metabolic resources, namely sugars and fat.

20 Jan 2021

Researchers define cancer invasion machinery orchestrated by cancer gene

Researchers at the University of Helsinki have defined a cancer invasion machinery, which is orchestrated by a frequently mutated cancer gene called Ras. When signaling from Ras protein becomes abnormally high, like it does in many cancers, this switches on the cellular machinery that helps the cancer cells to depart from the tissue from which the cells have developed.

20 Jan 2021

New mathematical model captures forces involved in cell movement

Physicists have teamed up to find out the precise mechanisms that play a crucial role in cell motility.

19 Jan 2021

Gene therapy helps paralyzed mice to walk again

For the first time, scientists have successfully used gene therapy to make mice walk again after these animals suffered a complete cross-sectional injury.

18 Jan 2021

Study explains operating mode of mitochondrial sorting and assembly machinery

Mitochondria are vital for the human body as cellular powerhouses: They possess more than 1,000 different proteins, required for many central metabolic pathways. Disfunction of these leads to severe diseases, especially of the nervous system and the heart.

18 Jan 2021

Study identifies gene networks that control sugar and organic acid metabolism during fruit development

The watermelon and melon cultivation project by researchers achieved a new advancement in controlling the metabolism of sugar in watermelon fruit.

15 Jan 2021

Researchers develop more effective personalized immunotherapy for cancer patients

New research from CU Cancer Center member Jing Hong Wang, MD, PhD, and recent University of Colorado Immunology program graduate Rachel Woolaver, PhD, may help researchers develop more effective personalized immunotherapy for cancer patients.

15 Jan 2021

Study shows how AFV3-109 protein with slipknot structure folds and unfolds based on temperature

Scientists from the Pacific Quantum Center of Far Eastern Federal University (FEFU) figured out how the AFV3-109 protein with slipknot structure folds and unfolds depending on temperature. The protein is typical for the viruses of the oldest single-celled organisms that can survive in the extreme conditions of underwater volcanic sources - archaea. The research outcome appears in PLOS ONE.

15 Jan 2021

UT Southwestern biochemist is honoured for breakthrough metabolic research

UT Southwestern Biochemist Benjamin Tu, Ph.D., is the recipient of the 2021 Edith and Peter O'Donnell Award in Science from TAMEST (The Academy of Medicine, Engineering and Science of Texas). He was chosen for his pioneering research on cellular roles of small molecule metabolites that may have relevance for cancer treatments and other diseases.

15 Jan 2021

Dual Detector Enables Sensitive Determination of Molecular Weight Distribution

Testa Analytical Solutions e.K reports on the development and OEM supply of a novel combination refractive index/viscometry detector for Brookhaven Instruments Corporation (Holtsville, NY, USA).

From TESTA Analytical Solutions 14 Jan 2021

Dual Detector Enables Sensitive Determination of Molecular Weight Distribution

Testa Analytical Solutions e.K reports on the development and OEM supply of a novel combination refractive index/viscometry detector for Brookhaven Instruments Corporation (Holtsville, NY, USA).

From Ziath Ltd 14 Jan 2021

New barcoding system improves portable DNA sequencing to monitor pathogens more effectively

Scientists have discovered an easy way to remove nearly all sequencing errors created by a commonly used portable DNA sequencer.

13 Jan 2021

Scientists use gene-editing technique to considerably increase the production of formicamycin antibiotics

Researchers have leveraged gene-editing advances to obtain a 10 times increase in the development of super-bug targeting formicamycin antibiotics.

13 Jan 2021

Protein phosphatase inhibition could contribute to the treatment of cancer, other diseases

The abundant presence of an enzyme known as low molecular weight protein tyrosine phosphatase (LMWPTP) in tumor cells has long been considered an indicator of cancer aggressiveness and metastatic potential.

13 Jan 2021

Nanobodies can prevent entry of SARS-CoV-2 coronavirus into human cells

Researchers at Karolinska Institutet in Sweden have developed, in collaboration with researchers in Germany and the U.S., new small antibodies, also known as nanobodies, which prevent the SARS-CoV-2 coronavirus from entering human cells.

13 Jan 2021

Researchers determine atomic structure of coronavirus protein linked to disease severity

A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells.

13 Jan 2021

Study reveals richness of space-time gene expression dynamics of the liver

Nothing in biology is static. Biological processes fluctuate over time, and if we are to put together an accurate picture of cells, tissues, organs etc., we have to take into account their temporal patterns. In fact, this effort has given rise to an entire field of study known as "chronobiology".

12 Jan 2021

Automated electron microscopy helps visualize neural function and behavior

Researchers are still clueless about how the neural networks are linked together to make functional circuits.

From Harvard Medical School 12 Jan 2021

New discovery helps explain how COVID-19 suppresses the body’s immune response

Seeking to understand why COVID-19 is able to suppress the body's immune response, new research from the USC Leonard Davis School of Gerontology suggests that mitochondria are one of the first lines of defense against COVID-19 and identifies key differences in how SARS-CoV-2, the virus that causes COVID-19, interacts with mitochondrial genes when compared to other viruses.

12 Jan 2021

Two cryo-EM studies identify different types of ATP synthase organization

The mitochondrial ATP synthase is energy-converting macromolecular machine that uses the electrochemical potential across the bioenergetic membrane called cristae. This potential is maintained via a membrane curvature that is induced by ATP synthase assembled in dimers.

11 Jan 2021

Molecular & Structural Biology

Functions of gamma delta T cells are regulated by sugars and fat Gene, shows study

Researchers define cancer invasion machinery orchestrated by cancer gene

New mathematical model captures forces involved in cell movement

Gene therapy helps paralyzed mice to walk again

Study explains operating mode of mitochondrial sorting and assembly machinery

Study identifies gene networks that control sugar and organic acid metabolism during fruit development

Researchers develop more effective personalized immunotherapy for cancer patients

Study shows how AFV3-109 protein with slipknot structure folds and unfolds based on temperature

UT Southwestern biochemist is honoured for breakthrough metabolic research

Dual Detector Enables Sensitive Determination of Molecular Weight Distribution

Dual Detector Enables Sensitive Determination of Molecular Weight Distribution

New barcoding system improves portable DNA sequencing to monitor pathogens more effectively

Scientists use gene-editing technique to considerably increase the production of formicamycin antibiotics

Protein phosphatase inhibition could contribute to the treatment of cancer, other diseases

Nanobodies can prevent entry of SARS-CoV-2 coronavirus into human cells

Researchers determine atomic structure of coronavirus protein linked to disease severity

Study reveals richness of space-time gene expression dynamics of the liver

Automated electron microscopy helps visualize neural function and behavior

New discovery helps explain how COVID-19 suppresses the body’s immune response

Two cryo-EM studies identify different types of ATP synthase organization

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