Molecular & Structural Biology

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Study shows how AFV3-109 protein with slipknot structure folds and unfolds based on temperature

Scientists from the Pacific Quantum Center of Far Eastern Federal University (FEFU) figured out how the AFV3-109 protein with slipknot structure folds and unfolds depending on temperature. The protein is typical for the viruses of the oldest single-celled organisms that can survive in the extreme conditions of underwater volcanic sources - archaea. The research outcome appears in PLOS ONE.

15 Jan 2021

UT Southwestern biochemist is honoured for breakthrough metabolic research

UT Southwestern Biochemist Benjamin Tu, Ph.D., is the recipient of the 2021 Edith and Peter O'Donnell Award in Science from TAMEST (The Academy of Medicine, Engineering and Science of Texas). He was chosen for his pioneering research on cellular roles of small molecule metabolites that may have relevance for cancer treatments and other diseases.

15 Jan 2021

Dual Detector Enables Sensitive Determination of Molecular Weight Distribution

Testa Analytical Solutions e.K reports on the development and OEM supply of a novel combination refractive index/viscometry detector for Brookhaven Instruments Corporation (Holtsville, NY, USA).

From TESTA Analytical Solutions 14 Jan 2021

Dual Detector Enables Sensitive Determination of Molecular Weight Distribution

Testa Analytical Solutions e.K reports on the development and OEM supply of a novel combination refractive index/viscometry detector for Brookhaven Instruments Corporation (Holtsville, NY, USA).

From Ziath Ltd 14 Jan 2021

New barcoding system improves portable DNA sequencing to monitor pathogens more effectively

Scientists have discovered an easy way to remove nearly all sequencing errors created by a commonly used portable DNA sequencer.

13 Jan 2021

Scientists use gene-editing technique to considerably increase the production of formicamycin antibiotics

Researchers have leveraged gene-editing advances to obtain a 10 times increase in the development of super-bug targeting formicamycin antibiotics.

13 Jan 2021

Protein phosphatase inhibition could contribute to the treatment of cancer, other diseases

The abundant presence of an enzyme known as low molecular weight protein tyrosine phosphatase (LMWPTP) in tumor cells has long been considered an indicator of cancer aggressiveness and metastatic potential.

13 Jan 2021

Nanobodies can prevent entry of SARS-CoV-2 coronavirus into human cells

Researchers at Karolinska Institutet in Sweden have developed, in collaboration with researchers in Germany and the U.S., new small antibodies, also known as nanobodies, which prevent the SARS-CoV-2 coronavirus from entering human cells.

13 Jan 2021

Researchers determine atomic structure of coronavirus protein linked to disease severity

A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells.

13 Jan 2021

Study reveals richness of space-time gene expression dynamics of the liver

Nothing in biology is static. Biological processes fluctuate over time, and if we are to put together an accurate picture of cells, tissues, organs etc., we have to take into account their temporal patterns. In fact, this effort has given rise to an entire field of study known as "chronobiology".

12 Jan 2021

Automated electron microscopy helps visualize neural function and behavior

Researchers are still clueless about how the neural networks are linked together to make functional circuits.

From Harvard Medical School 12 Jan 2021

New discovery helps explain how COVID-19 suppresses the body’s immune response

Seeking to understand why COVID-19 is able to suppress the body's immune response, new research from the USC Leonard Davis School of Gerontology suggests that mitochondria are one of the first lines of defense against COVID-19 and identifies key differences in how SARS-CoV-2, the virus that causes COVID-19, interacts with mitochondrial genes when compared to other viruses.

12 Jan 2021

Two cryo-EM studies identify different types of ATP synthase organization

The mitochondrial ATP synthase is energy-converting macromolecular machine that uses the electrochemical potential across the bioenergetic membrane called cristae. This potential is maintained via a membrane curvature that is induced by ATP synthase assembled in dimers.

11 Jan 2021

New deep neural network predicts transcription factors from protein sequences

A collaborative team of researchers have developed a deep neural network called DeepTFactor that predicts transcription factors from protein sequences.

8 Jan 2021

Disease-induced microbial shifts indicate new management strategies for crops

While humans are facing the raging COVID-19 pandemic, the citrus industry is attempting to control its own pernicious disease, Huanglongbing (HLB), which is also called citrus greening disease.

8 Jan 2021

New class of protein materials can influence cell signaling

A new study has revealed that a novel class of protein material that communicates with living cells without being absorbed by them can affect cell signaling. The protein material does this by attaching and sequestering cell surface receptors.

7 Jan 2021

Study may lead to new treatments for autoimmune diseases

According to a research team, headed by Decio L. Eizirik, MD, PhD, a Scientific Director from the Indiana Biosciences Research Institute Diabetes Center, new treatments for autoimmune disorders can be identified by studying both target tissues and the immune system together.

7 Jan 2021