Proteomics

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Deep Learning Methods Developed For Computational Protein Design

The key to understanding proteins -; such as those that govern cancer, COVID-19, and other diseases -; is quite simple. Identify their chemical structure and find which other proteins can bind to them. But there's a catch.

11 Aug 2023

Analyzing Deep Learning Methods for Computational Protein Design

4 Aug 2023

New Nanopore Technology Can Identify Single-Molecule Protein Variations

A group of researchers guided by the University of Oxford has made significant progress in detecting changes in protein structures. The method, which was published in Nature Nanotechnology, uses novel nanopore technology to detect structural variations at the single-molecule level, even deep within long protein chains.

2 Aug 2023

Looking at Protein Function in Preventing Female Obesity

Obesity is on the rise in the US, which is linked to worse health outcomes and a lower quality of life. Over 30% of American individuals are currently considered fat. Obesity is a significant and expanding public health issue since it is a risk factor for several diseases, including diabetes, cardiovascular disease, and COVID-19.

26 Jul 2023

In-Cell Engineering Proves to be a Powerful Tool for Synthesizing Functional Protein Crystals

In-cell engineering can be a powerful tool for synthesizing functional protein crystals with promising catalytic properties, show researchers at Tokyo Tech.

26 Jul 2023

New Process by Which Enzymes Help Prevent Heart Damage in Chemotherapy Patients Identified

Researchers at the University of Illinois Chicago have identified a process by which enzymes can help prevent heart damage in chemotherapy patients.

21 Jul 2023

New Simulations Reveal How Nuclear Pore Complex Regulates Protein Trafficking

If the human cell is a nightclub, then the nucleus is a VIP lounge. Inside are the DNA, fiercely maintained by the nuclear pore complex, which is charged with the task of protecting every strand. To do this, the NPC acts as gatekeeper against unworthy proteins.

14 Jul 2023

Xenogeneic-Free Brain Organoids Offer New Hope for Studying Neurodegenerative Diseases

Researchers at University of Michigan developed a method to produce artificially grown miniature brains -; called human brain organoids -; free of animal cells that could greatly improve the way neurodegenerative conditions are studied and, eventually, treated.

14 Jul 2023

Researchers Uncover Astonishing Diversity of Protein Structures Previously Unexplored

The astounding variety of protein structures and their folds in nature has been further illuminated by a ground-breaking discovery. Researchers wanted to know how much of the huge range of potential protein structures nature had examined.

12 Jul 2023

Unknown Membrane Proteins for Ovarian Cancer Diagnosis

Three previously undiscovered membrane proteins in ovarian cancer have been discovered by a study led by Nagoya University in Japan.

10 Jul 2023

Negative Modulation of Arabidopsis Salinity Tolerance by CONSTANS Protein

Arabidopsis (Arabidopsis thaliana)’s photoperiodically controlled flowering and circadian pathways are primarily regulated by CONSTANS (CO), a well-known B-box family member.

5 Jul 2023

Mechanisms of MCL-1 Inhibitor-Induced MCL-1 Protein Upregulation and Induction of Apoptosis

A new editorial paper was published in Oncotarget's Volume 14 on June 21, 2023, entitled, "Decoding the mechanism behind MCL-1 inhibitors: A pathway to understanding MCL-1 protein stability."

29 Jun 2023

Establishing the Flour Reference Proteome for Five Wheat Species

The protein composition of the five types of wheat—einkorn, emmer, spelt, durum, and common wheat—and their varieties differ widely.

20 Jun 2023

New Way to Conduct Extensive Proteome Analysis of Urine

Urine is one of the alluring sources for early and sensitive biomarker discovery because it can accumulate and indicate changes in the human body while still being obtained non-invasively.

16 Jun 2023

Study Revolutionizes the Understanding of Immune Signaling

A study led by Daniel Jane-Wit, MD, PhD, associate professor of medicine (cardiology) and of immunobiology, could revolutionize our understanding of immune signaling.

14 Jun 2023

Natural Peptide From Fruit Flies may Pave Way for New Antibiotics

Scientists at the University of Illinois Chicago have found that a peptide from fruit flies could lead to new antibiotics.

7 Jun 2023

Machine Learning-Based Tool Allows Scientists to Quickly Model Families of Proteins

Microbes drive key processes of life on Earth. They affect global elemental cycles-;the movement of carbon, nitrogen, and other elements. They also promote plant growth and affect the development of diseases. These roles are essential in every ecosystem.

2 Jun 2023