Proteomics

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Newest variant of mScarlet3 to help track protein movements in living cells

Biologists frequently utilize a method to figure out why a cell divides, secretes hormones, or sends a signal to another cell. They attach colored lights to the proteins of interest so that they can see their motions and interactions in living cells under a microscope.

28 Mar 2023

Scientists develop a detailed "protein atlas" of a pathogen for the first time

A parasite which has devasting impacts on agriculture and human health is the first pathogen to have its proteins located and mapped within its cells – providing clues to their function and helping to identify potential drug targets.

27 Mar 2023

Meta-scale approach to quantifying the protein variants in the human body

A key conundrum in biology is why many very simple creatures, such as the widely studied worm C. elegans, have almost as many genes as the human genome, which has about 20,000 genes.

27 Mar 2023

Key gene involved in crop alkaline tolerance discovered

Chinese scientists have identified a key gene involved in crop alkaline tolerance that may greatly improve crop yield in sodic environments through the use of genetic engineering.

24 Mar 2023

Single mechanosensitive protein shown to contribute to fibrosis in multiple organs

Researchers from Kyushu University have found how a single mechanosensitive protein induces the process that thickens and scars tissue, known as fibrosis. The protein, called VGLL3, was shown to contribute to fibrosis in multiple organs.

23 Mar 2023

Novel low oxygen signaling pathway discovered in the Arabidopsis plant

Aerobic reactions are essential to sustain plant growth and development. Impaired oxygen availability due to excessive water availability, e.g., during waterlogging or flooding, reduces plant productivity and survival.

22 Mar 2023

Tardigrade proteins for significant advancement in human health

Researchers at the University of Wyoming have made a significant discovery that could one day allow people living in areas without refrigeration to access life-saving treatments.

21 Mar 2023

Uncovering the role of the third intracellular loop in the GPCR’s signaling mechanism

Over a one-third of FDA-approved drugs tend to function by targeting a G protein-coupled receptor, or so-called GPCR. The human body consists of over 800 kinds of GPCRs that offer cells with data concerning the external surrounding to calibrate responses.

20 Mar 2023

The protein synthesis mechanism in the Giardia parasite

Cryo-electron microscopy was employed by Uppsala University researchers to reveal information on the protein synthesis mechanism in the parasite Giardia intestinalis, which causes diarrhea. The new findings could help in the development of specific medicines to combat Giardia and other protozoan parasites.

20 Mar 2023

Researchers uncover the role of third intracellular loop in GPCR's signaling mechanism

More than a third of FDA-approved drugs work by targeting a G protein-coupled receptor, or GPCR. The human body has more than 800 types of GPCRs that provide cells with information about the external environment to calibrate responses.

20 Mar 2023

Highly sensitive bioluminescent platform for nucleic acid detection

Despite significant advances, numerous highly sensitive viral disease diagnostic tests even now require complex techniques to prepare a sample or decipher a result, making them inconvenient for point-of-care settings or areas with limited resources.

17 Mar 2023

TurboID-based proximity labeling in meiotic cells of Arabidopsis thaliana

During meiosis, reshuffling of genetic information between homologous chromosomes through meiotic recombination creates variable gametes and hence genetic variation in offsprings.

14 Mar 2023

Investigating the potential cellular effects of C-reactive protein

The biological function of the C-reactive protein, CRP, has long been unidentified. Investigators at LiU have discovered that this protein has a useful function in the inflammatory disease systemic lupus erythematosus or SLE.

10 Mar 2023

Potential therapeutic can synergize with existing drugs to effectively destroy leukemia cells

A team of researchers has discovered a potential therapeutic that can synergize with existing drugs to more effectively kill certain leukemia cells.

9 Mar 2023

Uncovering the complete 3D structure of p53 protein

By inducing cell repair or self-destruction, the tumor suppressor protein p53, often known as “the guardian of the genome,” shields the body’s DNA from daily stress or long-term damage.

2 Mar 2023

Novel way to block the death of nerve cells in MND

Scientists have found a novel way to block the transportation of mutant RNA and subsequent production of toxic repeat proteins which lead to the death of nerve cells in the most common subtypes of motor neurone disease (MND) and frontotemporal dementia (FTD).

2 Mar 2023