Proteomics, Metabolomics and Lipidomics News and Research

Latest Proteomics, Metabolomics and Lipidomics News and Research

Discovery of Lysosomal Vacuolation Mechanism Sheds Light on Aging and Disease

New research, published today in the journal Science, shows how lysosomes - organelles that act like cells' waste disposal system - respond to stress by becoming abnormally bloated, a process called lysosomal vacuolation that is associated with numerous diseases.

22 Aug 2025

Breakthrough Technique Enables Large-Scale Study of Polar and Ionic Metabolites

Researchers from the McCullagh Group in Oxford University's Department of Chemistry have published an innovative method in Nature Protocols today (22 August) that provides comprehensive analysis of metabolites found in cells, tissues and biofluids.

22 Aug 2025

Epigenetic Noise Enables Cells to Shift Identity and Influence Immunity

All cells in the body contain the same DNA, but different cell types express different genes; skin cells express genes for the skin, liver cells express liver genes, and so on.

21 Aug 2025

Computational Modeling Creates a Database for Improved Detection of Designer Drugs

How do you identify something no one has a test for? Designer drugs replicate the effects of known, illicit drugs but evade law enforcement.

21 Aug 2025

How Primary Cilia Shape the Fate of Fat Precursor Cells

Too much fat can be unhealthy: how fat cells, so-called adipocytes, develop, is crucial for the function of the fat tissue.

21 Aug 2025

New Tool Offers Insight Into When Genes Turn On and Off in the Brain

A Yale research team has created a new computer tool that can pinpoint when exactly genes turn on and off over time during brain development - a finding that may one day help doctors identify the optimal window to deploy gene therapy treatments.

20 Aug 2025

New Technology Maps Over 140 Proteins Across Human Tissues

Each organ in the human body contains different types of cells arranged in specific ways.

20 Aug 2025

MIT Researchers Unlock the Hidden Features of Protein Language Models

Within the past few years, models that can predict the structure or function of proteins have been widely used for a variety of biological applications, such as identifying drug targets and designing new therapeutic antibodies.

20 Aug 2025

Feline Dementia May Explain Synapse Loss in Alzheimers

The study uncovers amyloid-beta's role in glial-mediated synapse loss in feline cognitive dysfunction, enhancing understanding of Alzheimer's disease.

20 Aug 2025

New Insights Reveal Bacterial Roots of Key Plant Hormone Enzymes

Terpenoids play vital roles in plant ecology-from repelling pests to attracting pollinators-and are produced by terpene synthases (TPSs) enzymes.

19 Aug 2025

Missing Microexons Disrupt Synapse-Related Proteins in Pediatric Glioma

A new study, led by researchers at Children's Hospital of Philadelphia (CHOP), identified tiny pieces of messenger RNA that are missing in pediatric high-grade glioma tumors but not in normal brain tissues.

19 Aug 2025

Amino Acids as Key Mediators in the Tumor Immune Dialogue

The tumor microenvironment is not just a site of cancer growth—it is a high-stakes metabolic contest where tumor and immune cells vie for limited resources.

19 Aug 2025

New Enzyme Technology Illuminates Hidden Sugar Patterns on Cells

Sugars known as glycans form dense envelopes around cells. But they're often ignored in biological investigations because, unlike DNA, proteins and other cellular components, tools to study them are lacking.

18 Aug 2025

Fruit Fly Courtship Behavior Transferred Through Single Gene Manipulation

Researchers in Japan have genetically transferred a unique courtship behavior from one fruit fly species to another.

18 Aug 2025

New Method Enables Human Cells to Initiate Meiosis Outside the Body

More than one-sixth of adults around the world experience infertility in their lifetime. There is a high unmet need not only for increased access to affordable, high-quality fertility care for those in need but, importantly, also for new biomedical solutions that can address the root causes of infertility.

18 Aug 2025