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Epigenetic Clocks Offer Insight into Biological Age at Cell-Type Resolution

A new priority research paper, featured as the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 22, was published on December 29, 2024. The paper is titled "Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution."

3 Jan 2025

Unveiling the Impact of Antigen History on CAR-T Cell Function

The memory of previous interactions with bacteria, viruses, and other antigens is carried by some CAR-T cells that have been engineered to fight cancer and other conditions, according to research from the University of Colorado Anschutz Medical Campus.

3 Jan 2025

Bacterial Protein Enables 2D Culture of Organoids

The Organoid group’s researchers devised a novel method for growing organoids. Organoids are miniature organs that are created in a lab and resemble the original organ.

2 Jan 2025

Stress Pathway in Microglia Found to Contribute to Alzheimer's Neurodegeneration

Researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have unveiled a critical mechanism that links cellular stress in the brain to the progression of Alzheimer's disease (AD).

26 Dec 2024

New Platform Simplifies Protein-Protein Interaction Measurements

A team led by researchers at the University of Toronto has created a platform, called SIMPL2, that revolutionizes the study of protein-protein interactions by simplifying detection while improving measurement accuracy.

26 Dec 2024

New Method Improves Quantification of Endocytosis in Living Cells

Living cells and tissues show a high capacity to absorb various chemical compounds from the surrounding environment.

23 Dec 2024

Discovery of ALAS1's Secret Role Could Boost Cancer Therapy Development

In everyday life, when things turn out the opposite of what you expect, it's usually cause for frustration. In science, it's often the starting point for discovery.

23 Dec 2024

New Discovery Reveals How Tumor Stiffness Drives Cancer Progression

In 2022 alone, over 20 million people were diagnosed with cancer, and nearly 10 million died from the disease, according to the World Health Organization.

23 Dec 2024

Extracellular Vesicles from Mesenchymal Stromal Cells Restore Joint Health in Osteoarthritis

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 21 on November 22, 2024, entitled, "Anti-aging effect of extracellular vesicles from mesenchymal stromal cells on senescence-induced chondrocytes in osteoarthritis."

20 Dec 2024

ALS Stem Cell Model Reveals Increased Susceptibility to Cell Death

Amyotrophic lateral sclerosis (ALS) is a fast-progressing neurodegenerative disease with an average survival time of three years. In ALS, certain types of neurons called motor neurons that are required for muscle contractions die off, leading to progressive paralysis affecting most muscles of the body. The molecular causes of ALS are poorly understood, and effective treatments are missing.

20 Dec 2024

Engineering Yeast Promoters for Biologic Manufacturing

When introducing genes into yeast to make it produce drugs and other useful substances, it is also necessary to reliably switch the production on or off. A Kobe University team found three gene regulation design principles that provide a flexible guideline for the effective control of microbiological production.

19 Dec 2024

Researchers Uncover Ketamine’s Effect on Astrocytes in Zebrafish

The decades-old anesthetic ketamine could be a game changer for treating severe depression, but there are still many questions about how the drug works, including exactly how it affects the brain's cells and circuits.

18 Dec 2024

Terumo Blood and Cell Technologies Presents Data on Automated Red Blood Cell Exchange to Treat Sickle Cell Disease at the American Society of Hematology

The abstracts highlight the potential to improve SCD treatment using aRBCX. The first poster presents data from U.S. insurance claims, examined in a study performed with researchers at University of Pittsburgh.

18 Dec 2024

Researchers Map Influenza Virus RNA Protective Coat at Atomic Level

To fight the virus that causes influenza, one of the avenues being explored by scientists is the development of drugs capable of destabilizing its genome, made up of eight RNA molecules.

17 Dec 2024

Researchers Uncover Lamin A's Role in DNA Repair and Premature Aging Disease

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have discovered how a protein called lamin A helps repair the protective barrier around a cell's DNA.

16 Dec 2024

Deadly Mould Strains Highly Likely to Acquire Resistance to New Drugs

Scientists have identified strains of one of the world’s most dangerous fungal pathogens, already resistant to our most effective antifungal drugs, which are also 5-times more likely to acquire resistance to desperately needed new treatments in development.

From The University of Manchester 16 Dec 2024

Discovery of 18-Digit Code Unlocks Exosome-Based Drug Delivery

Researchers at The Ottawa Hospital and the University of Ottawa have discovered an 18-digit code that allows proteins to attach themselves to exosomes - tiny pinched-off pieces of cells that travel around the body and deliver biochemical signals.

12 Dec 2024

Programmable G-protein-coupled receptors redefine therapeutic applications.

This study demonstrates the development of PAGERs (programmable antigen-gated engineered receptors), combining antigen specificity, modular adaptability, and drug-controlled activation, with potential applications in synthetic biology, therapeutics, and neuroscience.

12 Dec 2024

Biomaterials to Regenerate the Nervous System: Carl Zeiss Foundation Sponsors InteReg Project at Mainz University

Collaborative project involving Johannes Gutenberg University Mainz, the Max Planck Institute for Polymer Research, and the Leibniz Institute for Resilience Research will receive EUR 6 million.

11 Dec 2024

Study Reveals How Toxoplasma Parasite Evades Drug Treatment by Altering Protein Production

A study by Indiana University School of Medicine researchers sheds new light on how Toxoplasma gondii parasites make the proteins they need to enter a dormant stage that allows them to escape drug treatment.

10 Dec 2024