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Scientists find gene signature linked to worst prognosis in rare uterine cancer

Women who don't survive a rare and aggressive uterine cancer called uterine serous carcinoma, have high expression of a group of 73 genes, a score scientists say can help identify these women and improve their outcome.

22 Apr 2020

New database of 14,000 known macrolactones could aid future drug discovery

Researchers from North Carolina State University and Collaborations Pharmaceuticals have created a free-to-use database of 14,000 known macrolactones - large molecules used in drug development - which contains information about the molecular characteristics, chemical diversity and biological activities of this structural class.

22 Apr 2020

Study shows how tumor cells respond to nutrient deficiency

Some solid tumors have a very high growth rate, which often leads to a lack of vascularization due to the impossibility to develop, at the same time, the blood vessels that accompany and nourish it.

22 Apr 2020

Biophysicists uncover new features of molecular elevator

Biophysicists from the Moscow Institute of Physics and Technology and the University of Groningen in the Netherlands have visualized a nearly complete transport cycle of the mammalian glutamate transporter homolog from archaea.

21 Apr 2020

A novel prediction method for promising antiviral drug or vaccine targets

A novel method to predict the most promising targets for antiviral drugs or vaccines is based on the conformational changes viral glycoproteins go through during the process of recognition and binding to the host cell.

21 Apr 2020

Discovery marks a critical step toward developing new anti-cancer drugs

A team of scientists led by the University of Michigan Rogel Cancer Center and Case Comprehensive Cancer Center has identified the binding site where drug compounds could activate a key braking mechanism against the runaway growth of many types of cancer.

21 Apr 2020

Glycomimetics can prevent viruses from infecting cells

Viruses are responsible for causing many different diseases, with the present coronavirus pandemic being one such example. Hence, these infectious agents are part of the human experience all through their lives.

21 Apr 2020

Study pinpoints a key brain region for controlling binge drinking

A team of National Institutes of Health-funded researchers at the Medical University of South Carolina has found that deactivating a stress-signaling system in a brain area known for motivation and emotion-related behaviors decreases binge drinking.

20 Apr 2020

Study Reveals Bile Metabolite Of Gut Microbes Boosts Immune Cells

A study has discovered a novel means by which bacterial colonies in the small intestine support the generation of regulatory T cells.

20 Apr 2020

Cancer Drug Resistance Study Raises Immune Red Flags

Sooner or later, most cancer patients develop resistance to chemotherapy drugs designed to kill their cancer, forcing oncologists to seek alternatives.

20 Apr 2020

Sensitive technique makes it possible to study the delivery of RNA drugs

In recent years, RNA molecules, with the ability to affect or turn off pathogenic genes, have become promising drug candidates in several areas.

17 Apr 2020

Rare structural genetic variants could play a role in schizophrenia

Most of the research focused on the genetics of schizophrenia has aimed at understanding the function played by genes in the development and heritability of schizophrenia.

17 Apr 2020

Synapses of the human nervous system

The glutamate receptors do not actually adhere to “distance keeping.” Now, high-resolution microscopic studies have revealed that the receptors often appear in small groups at the synapses and remain in contact with other proteins.

17 Apr 2020

Gene Variant Staves Off Alzheimer's In Some People

People with a gene that puts them at risk for Alzheimer's disease are protected from its debilitating effects if they also carry a variant of a different gene.

17 Apr 2020

Computer Model Predicts How Drugs Affect Heart Rhythm

UC Davis Health researchers have developed a computer model to screen drugs for unintended cardiac side effects, especially arrhythmia risk.

From The University of California, Davis 17 Apr 2020

Whole Genome Sequencing Reveals Secrets Of Schizophrenia

Most research about the genetics of schizophrenia has sought to understand the role that genes play in the development and heritability of schizophrenia.

17 Apr 2020

New optical imaging technology makes fluorescence microscopy more efficient

Scientists have been using fluorescence microscopy to study the inner workings of biological cells and organisms for decades.

16 Apr 2020

Single-cell cloning can lead to new therapies for COPD

Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of death around the world. Now, two internationally acclaimed stem cell experts have discovered a large number of abnormal stem cells found in the lungs of COPD patients.

16 Apr 2020

Identifying Potential Drugs Earlier In Discovery

Scientists have developed a technique that could significantly reduce the time of discovering potential new antibody-based drugs to treat disease.

16 Apr 2020

Scientists determine first 3D structure of COVID-19 main protease

A team of Chinese scientists has reported the high-resolution crystal structure of the main protease (Mpro) of the COVID-19 virus and has identified drugs that may hold promise in combating the virus.

15 Apr 2020