Kinase News and Research

RSS

Molecular Map Matches Patient Tumors to Targeted Clinical Trial Therapies

A new molecular map of breast cancer has identified novel forms of the disease and provides a foundation for selecting personalized treatments guided by a tumor's molecular characteristics rather than standard pathology alone.

6 Nov 2026

KARAP Deficiency Enhances Macrophage IL-10 Production and Epithelial Barrier Repair

Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease in which persistent mucosal inflammation damages the epithelial barrier.

5 Nov 2026

Nanoparticle Displayed Antibody Fragments Ease Asthma Associated Goblet Cell Hyperplasia

Airway mucus is part of innate lung defense, but when production overwhelms clearance, it obstructs airflow and worsens disease.

4 Nov 2026

Why a Breakthrough Blood Cancer Drug Could be Better for Patients

A more effective and better-tolerated treatment for chronic myeloid leukaemia (CML) could improve quality of life for people living with the disease.

27 Oct 2026

Dendritic Cell STING Activation Licenses Cytotoxic T Lymphocyte Priming

Immune checkpoint inhibitors (ICIs) have transformed cancer care, yet only a subset of patients benefit. A major barrier is tumor microenvironment (TME) heterogeneity: "hot" tumors are enriched with cytotoxic T lymphocytes (CTLs) and respond better, while "cold" tumors lack T-cell infiltration or are shielded by immunosuppressive barriers.

20 Oct 2026

Comprehensive Analysis of Emerging Strategies for Targeting Cyclin-Dependent Kinases in Cancer

More than 30 years after the direct connection was established between the molecular machinery controlling cell division and cancer, a new paper traces the evolution of cyclin-dependent kinase research and outlines the next generation of CDK-targeted therapies.

15 Oct 2026

USP15 Protein May Help Ovarian Cancer Resist Chemotherapy

Blocking USP15 in ovarian cancer cells disrupts growth and enhances chemotherapy sensitivity, revealing a potential target for overcoming treatment resistance.

1 Oct 2026

Experts Extend Lives of Animals By Activating ‘Energy Saver’ Mode

The study, published today in Aging Cell, found strong evidence that triggering a protein governing energy level may help organisms live longer, in some cases by over 25%.

1 Oct 2026

A Flash of Blue Light Helped Cells Overcome a Major Division Defect

Cell division represents a complex process. Central to this intricacy is a cellular structure devoid of a membrane, known as the centrosome, consisting of over 200 different components.

30 Sep 2026

Study Provides Novel Structural Model for CaMKIIα Synaptic Accumulation

Researchers at the Nano Life Science Institute (WPI-NanoLSI) at Kanazawa University, Kyoto University, SOKENDAI, and the National Institute for Physiological Sciences have revealed how CaMKIIα-a key brain protein involved in learning and memory-organizes itself into chain-like structures.

17 Sep 2026

Loss of Matrix Receptors Impairs Actin Cytoskeleton Remodeling, Cell Spreading, and Osteogenic Differentiation

During bone healing, skeletal progenitor cells (SPCs), which can multiply and develop into bone-forming cells, move to the injury site and help build new bone.

9 Sep 2026

Protein Interaction Helps Senescent Cells Survive Aging and Cellular Stress

Senescent cells - cells that have stopped dividing but remain metabolically active - can accumulate with age and contribute to chronic inflammation and tissue dysfunction

2 Sep 2026

Scientists Find Cancer Gene Forcing Zombie Cells to Cause Aging

In a tale of identities as divergent as "The Prince and the Pauper," a well-known cancer-causing gene also influences cells in a zombie-like state meant to prevent cancer.

31 Aug 2026

Genomic Database Analysis Identifies New Target for Triple-Negative Breast Tumors

Triple-negative breast cancer accounts for approximately 15% of all breast cancer cases. It is characterized by the absence of estrogen receptor, progesterone receptor, and HER2 expression, rendering it insensitive to conventional endocrine and targeted therapies.

13 Aug 2026

New Study Reveals How Genetic Mutations Hijack the Parkinson's LRRK2 Switch

Researchers at Weill Cornell Medicine have uncovered how a key Parkinson's protein called LRRK2 shifts between inactive and active forms, revealing the structural changes that enable certain mutations to push the protein into an overactive state.

11 Aug 2026

Mapping Alternative RNA Splice Isoforms to Identify Novel Therapeutic Targets

Proteogenomics represents a transformative approach in cancer research that bridges the gap between genomic alterations and their functional consequences at the protein level.

8 Aug 2026

New Research Bypasses Rapid Fungicide Resistance Through Cell Wall Disruption

Powdery mildew is among the most widespread crop diseases, affecting cereals, grapes, cucurbits, tomatoes, fruit crops, and ornamentals in fields and greenhouses.

5 Aug 2026

AI-Assisted Paper Test Measures Three Cardiac Biomarkers in 23 Minutes

Researchers developed an AI-assisted dual-mode paper assay that measures cTnI, CK-MB, and NT-proBNP from 50 µL of serum in 23 minutes. In single-site analytical validation, neural networks quantified the three biomarkers across distinct concentration ranges, supporting further development for multiplexed cardiac testing at the point of care.

27 Jul 2026

Research Maps Structural Mechanism Linking Amino Acid Availability to Cancer Growth

Cells carry their own growth switches. When enough nutrients-amino acids in particular-are available, cells flip this switch on and begin to grow. Researchers at KAIST and Yonsei University have now uncovered the molecular mechanism by which amino acid signals activate this cellular growth switch.

27 Jul 2026

Lipid Accumulation in Senescent Brain Cells Drives Aging and Alzheimer’s Disease

A new research paper was published in Volume 18 of Aging on July 1, 2026, titled "Senescent cells accumulate lipid droplets."

17 Jul 2026