Drug Discovery and Manufacturing News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Novel “green” synthesis of drug for inflammatory bowel disease

Steroids and antibody drugs are currently used to treat inflammatory bowel disease (IBD), which is characterized by chronic inflammation of the digestive tract.

16 Mar 2022

Researchers show how hotspot maps can detect structures contributing to compounds’ selectivity

The quantity of structural data available on protein drug targets keeps growing.

4 Mar 2022

Study finds a more sustainable way to develop pharmaceuticals

University of Bath’s chemistry researchers recently devised a novel process utilizing blue light to develop pharmaceuticals in sustainable means.

From University of Bath 19 Nov 2021

Research findings anticipated to facilitate production of novel drug candidates

Pharmaceuticals commonly available on the market are developed by linking together rings of molecules to generate drugs that treat conditions like depression.

19 Nov 2021

New visible-light-based approach to structurally modify bioactive molecules

Researchers have been working on new, sustainable techniques to synthesize chemicals by leveraging the inexhaustible, green energy of visible light.

10 Nov 2021

Researchers discover that existing drug can enhance memory

A group of scientists identified that a prevailing drug for treating constipation might boost an individual’s capability to think with better clarity.

4 Oct 2021

Study pinpoints means to restore the efficacy of drugs for acute myeloid leukemia

Researchers elucidate why certain drugs, in clinical trials, for treating a kind of acute myeloid leukemia often fail and revealed a means to restore their efficacy.

1 Oct 2021

Experts unravel inner workings of cell receptors involved in various diseases

Scientists revealed the operational mechanism of possible drug targets for numerous diseases like rheumatoid arthritis, cancer, and even COVID-19.

1 Oct 2021

Novel nanofluidic device for exosome nanoporation

A team of researchers described an innovative nanofluidic device for high-throughput preparation of exosome-based drug delivery vehicles.

8 Sep 2021

Study proposes a novel approach for developing safer analgesics

Opioids are potent painkillers; however, their use is hampered as patients become tolerant to them, necessitating more and more doses.

From The University of California, Davis 31 Aug 2021

Study pinpoints genes responsible for kidney function

Recently scientists pinpointed 182 genes likely responsible for kidney function—most of which can be targeted with existing drugs.

18 Aug 2021

Insect olfaction could be used to help develop drug screening techniques

Scientists investigated a key element of the insect olfactory system to analyze how this insight might help humans.

18 Aug 2021

Graphene covered with bactericidal molecules inhibits harmful biofilm formation

Bacterial infections associated with medical implants place a major burden on healthcare and cause great suffering to patients across the world.

11 Aug 2021

Researchers create new drug database to facilitate repurposing of drugs

Scientists developed a new open-access database with information on drug candidates and the process of metabolization of the drugs by the body.

5 Aug 2021

Study highlights novel approach for designing anti-viral drugs

Scientists are exploring a novel screening approach that concentrates on the recognition of virus-specific morphological changes in virus-infected cells.

4 Aug 2021

Researchers devise a new method for safer delivery of RNA drugs

Scientists have developed and tested a library of lipid-based compounds for the safe and effective delivery of RNA drugs to the lungs.

3 Aug 2021

Researchers develop a cost-effective and versatile approach for drug synthesis

Different factors influence the cost-effectiveness of drug synthesis, the amount of waste generated being one of those.

29 Jul 2021

Study identifies many small molecules that bind to certain areas of the SARS-CoV-2 genome

Scientists at Goethe University have now identified some regions of the SARS-CoV-2 genome that might be an ideal target for future drugs.

21 Jul 2021

$Microcrystal electron diffraction could help obtain potential pharmaceutical structures$

Microcrystal electron diffraction could help obtain potential pharmaceutical structures

In the process of drug development, solving structures of potential therapeutics with X-ray diffraction (XRD) has been a presumed, critical step so far.

16 Jul 2021