Cell Biology

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New 3D organoid model reveals a possible biological target for treating GEJ cancers

Researchers at Johns Hopkins Medicine say they have created a laboratory-grown three-dimensional "organoid" model that is derived from human tissue and designed to advance understanding about how early stages of cancer develop at the gastroesophageal junction (GEJ) — the point where the digestive system's food tube meets the stomach.

2 Dec 2022

Research could advance our understanding of evolution and the origins of cell motility

The origin of all biological movements, including walking, swimming, or flying, can be traced back to cellular movements; however, little is known about how cell motility arose in evolution.

1 Dec 2022

Microglial cells trigger inflammatory protective mechanisms in the immune system

Microglia, the brain’s own immune cells, are present in the central nervous system.

1 Dec 2022

Figuring out how immune cells prevent cognitive decline

Could Alzheimer’s disease and other types of cognitive decline be caused by the underproduction of immune cells that are poorly understood? It might, according to a Rutgers study published in Nature Immunology, and increasing these cells could undo the harm.

From Rutgers University 1 Dec 2022

Using nanotechnology and magnetic manipulations to bioengineer 3D neural networks

Neurons are the fundamental units of the brain and nervous system, the cells responsible for receiving sensory input from the external world, for sending motor commands to our muscles, and for transforming and relaying the electrical signals at every step in between.

30 Nov 2022

Revealing the mechanism that ensures genome stability in normal cells

To create new cells, the old cells must divide. This is a constant, frequent, and pervasive process that begins with conception and culminates with death.

30 Nov 2022

Lysis and hypotonic sonication buffers for ChIP assays

Offering complete disruption of cytoplasmic and nuclear membranes, Porvair Sciences Chromatrap® buffer chemistries are optimised for sonication and enzymatic shearing.

From Porvair Sciences Limited 29 Nov 2022

Plants can precisely tune the chemistry of petal surface to create bee-luring signals

Cambridge researchers led by CUBG Director, Professor Beverley Glover, have shown that plants can regulate the chemistry of their petal surface to create iridescent signals visible to bees.

25 Nov 2022

UC San Diego Alpha Clinic awarded $8 million to bring new stem cell-based therapies to patients

Stem cells show particular promise in treating diseases for which few other effective treatments exist.

25 Nov 2022

Improving potential of cellular therapies with CAR T therapy

CAR T cells, or engineered immune cells, have demonstrated to the world the potential of customized immunotherapies to treat blood cancers. Researchers have just released highly encouraging preliminary data for CAR T therapy in a small group of lupus patients.

25 Nov 2022

Fastest-evolved regions of the human genome diverged rapidly after split from chimpanzee ancestor

A team of Duke researchers has identified a group of human DNA sequences driving changes in brain development, digestion and immunity that seem to have evolved rapidly after our family line split from that of the chimpanzees, but before we split with the Neanderthals.

24 Nov 2022

Launch of stem cells into space to investigate stem cell aging

Lab tests on astronaut Scott Kelly’s blood cells after he returned from a year-long stay aboard the International Space Station (ISS) showed telomeric and pre-leukemic changes.

From UC San Diego 24 Nov 2022

Highlighting the potential of new techniques to study mental disorders

Researchers investigating the fundamental brain mechanics of autism spectrum disorder have discovered that a gene mutation known to be connected with the illness causes considerably more overstimulation of brain cells than in neuronal cells without the mutation.

23 Nov 2022

The critical role of amino acid sensing pathways in driving colorectal cancer

A dietary modification may be essential to improving colon cancer treatment, according to research from the University of Michigan Rogel Cancer Center.

22 Nov 2022

3D “mini eyes” provide insight into genetically induced blindness

The development of “mini eyes” by researchers at the UCL Great Ormond Street Institute of Child Health (UCL GOS ICH) has made it possible to study and comprehend the onset of blindness in the rare genetic disease known as Usher syndrome more.

From University College London 22 Nov 2022

Mitochondria play a crucial role in the regulation of the NF-κB signaling pathway

Mitochondria are highly regarded as the cell's powerhouse. However, these cellular organelles are essential for more than only energy production: Professor Konstanze Winklhofer and her colleagues at Ruhr University Bochum’s Faculty of Medicine have found that mitochondria play an essential role in signal transduction in innate immune pathways.

21 Nov 2022

Cell Biology

New 3D organoid model reveals a possible biological target for treating GEJ cancers

Research could advance our understanding of evolution and the origins of cell motility

Microglial cells trigger inflammatory protective mechanisms in the immune system

Figuring out how immune cells prevent cognitive decline

Using nanotechnology and magnetic manipulations to bioengineer 3D neural networks

Revealing the mechanism that ensures genome stability in normal cells

Lysis and hypotonic sonication buffers for ChIP assays

Plants can precisely tune the chemistry of petal surface to create bee-luring signals

UC San Diego Alpha Clinic awarded $8 million to bring new stem cell-based therapies to patients

Improving potential of cellular therapies with CAR T therapy

Fastest-evolved regions of the human genome diverged rapidly after split from chimpanzee ancestor

Launch of stem cells into space to investigate stem cell aging

Highlighting the potential of new techniques to study mental disorders

The critical role of amino acid sensing pathways in driving colorectal cancer

3D “mini eyes” provide insight into genetically induced blindness

Mitochondria play a crucial role in the regulation of the NF-κB signaling pathway

Waste disposal mechanism of mitochondria to remove mtDNA mutations

Revealing cancer development in people carrying inherited BRCA1 mutations

Investigating the direct effect of mutation on sperm behavior

New study figures out which patients will react to immunotherapy

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