Drug Discovery & Pharmaceuticals

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Drugs designed to lower alpha-ketoglutarate levels could help fight DIPG tumors

Every year, 150 to 300 children in the United States are diagnosed with diffuse intrinsic pontine gliomas (DIPGs), aggressive and lethal tumors that grow deep inside the brain, for which there are no cures.

19 Aug 2020

RNA-based therapeutic approach could be used to cure hereditary diseases

Short RNA molecules can be used as medication. Their effectiveness is based on the genetic information they carry: therapeutic RNA can bind to the body's own RNA and thus influence how it functions.

19 Aug 2020

New technique could accelerate drug research for various diseases

Alicyclic compounds are groups of organic chemical compounds that have led to the development of a number of medications.

19 Aug 2020

Novel receptor protein can be a promising treatment for COVID-19

A novel receptor protein that binds to the SARS-CoV-2 virus and prevents it from entering cells may hold promise for treating COVID-19 and other coronavirus-related diseases, according to research published online Aug. 4 in the journal SCIENCE.

18 Aug 2020

Sustainable biotechnological production of coral antibiotic

Thomas Brück saw the sea whip Antillogorgia elisabethae for the first time 17 years ago while diving on a research trip to the Bahamas.

18 Aug 2020

Novel molecule shown to have potential therapeutic effects for arthritis

Arthritis affects almost 2% of the world's population, or some 150 million people, and currently, there is no completely effective treatment for this chronic disease. A new molecule developed in the laboratory has been shown to have potential therapeutic effects.

12 Aug 2020

Researchers use genome editing to facilitate drug discovery based on natural fungus

Rice University scientists have won federal support for their pursuit of novel drugs to treat human disease.

11 Aug 2020

Researchers are developing therapeutic treatments for acute stroke

Every year in the United States, about 800,000 people experience a stroke. Many are left with neurological complications such as paralysis on one side of the body, speech and language problems, vision issues, behavioral changes, and memory loss.

10 Aug 2020

Test pinpoints which people with gonorrhea can be treated with ciprofloxacin

A test designed by UCLA researchers can pinpoint which people with gonorrhea will respond successfully to the inexpensive oral antibiotic ciprofloxacin, which had previously been sidelined over concerns the bacterium that causes the infection was becoming resistant to it.

10 Aug 2020

Researchers are testing new way to deliver vaccines through microneedle skin patches

A revolutionary new way to give vaccines through microneedle skin patches is being tested at Swansea University, thanks to £200,000 of EU funding announced by the Welsh Government.

10 Aug 2020

Researchers find new way to create natural compound that shows promise as anti-cancer agent

Scripps Research chemists Hans Renata, PhD, and Alexander Adibekian, PhD, have discovered a way to efficiently create a synthetic version of a valuable natural compound called cepafungin I, which has shown promise as an anti-cancer agent.

7 Aug 2020

A New Way of Killing Tuberculosis

AZoLifeSciences speaks to Dr. Tim Blower about his research into tuberculosis, and how the discovery of a new toxin could lead to new anti-TB drugs.

From Durham University 5 Aug 2020

Researchers develop scalable strategy to find novel molecular glue degraders

Despite immense efforts to improve pharmacology methods, over three-quarters of all human proteins still remain beyond the reach of therapeutic advancement.

5 Aug 2020

Broad antivirals can kill several types of coronaviruses in human cells and mice

team of scientists has engineered antiviral compounds that can kill several types of coronaviruses, including SARS-CoV-2, the virus that causes COVID-19.

4 Aug 2020

Machine learning can increase effectiveness of drug repurposing for psychiatric disorders

Artificial intelligence can increase the effectiveness of drug repositioning or repurposing research, according to a study published in Translational Psychiatry.

4 Aug 2020

A simple screening process may improve mAb-based drug development

By screening potential monoclonal antibody (mAb)-based drugs solely based on a measure of their colloidal stability, scientists may be able to weed out mAbs that do not respond efficiently in solution early in the drug discovery process, according to a new study.

3 Aug 2020

Rapid drug development yields potential treatment for yellow fever

Yellow fever, a hemorrhagic disease that is common in South America and sub-Saharan Africa, infects about 200,000 people per year and causes an estimated 30,000 deaths.

From Massachusetts Institute of Technology (MIT) 30 Jul 2020

New technology can speed up drug development for tuberculosis

A novel technology that integrates machine learning and high-throughput imaging could accelerate drug discovery to fight tuberculosis (TB).

27 Jul 2020

Reactivating divergent signaling pathways to enhance cancer treatment

In order for cancer to form in the human body, normal cells must acquire multiple mutations before they develop toward the disease. It was previously believed that these mutations acted in concert in the progression of cancer.

23 Jul 2020

New startup launched to overcome the challenge of delivering next-generation therapeutics

Harvard University's Office of Technology Development (OTD) and the Harvard T.H. Chan School of Public Health today announced the launch of Vesigen Therapeutics, a startup company that aims to overcome the challenge of delivering next-generation therapeutics, such as gene-editing complexes, RNA molecules, and other large proteins, to intracellular targets in specific tissues of interest.

23 Jul 2020