Molecular & Structural Biology

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A protein in the lung forms a natural protective barrier against SARS-CoV-2 infection

University of Sydney scientists have discovered a protein in the lung that blocks SARS-CoV-2 infection and forms a natural protective barrier in the human body.

10 Feb 2023

Protein-rich droplets in cells linked to many unresolved diseases

Most proteins localize to distinct protein-rich droplets in cells, also known as "cellular condensates". Such proteins contain sequence features that function as address labels, telling the protein which condensate to move into.

9 Feb 2023

Semi-quantitative system employs eDNA to detect endangered species

Alteration in river systems, overfishing, and the introduction of new, invasive species can all lead to a significant decrease in the number of native fish found in aquatic ecosystems.

8 Feb 2023

Study elucidates the structure of centromeric region in chicken cells

The genetic material inside cells is organized into structures called chromosomes. The centromere is essential for the correct division of the chromosomes via interaction with spindle microtubules when cells divide and grow.

7 Feb 2023

Newly discovered gene signature accurately predicts the functioning of P53 variants

In a paper published in PNAS, Maureen Murphy, Ph.D., Deputy Director of Wistar's Ellen and Ronald Caplan Cancer Center and Ira Brind Professor and Program Leader in the Molecular & Cellular Oncogenesis Program, and team have identified a gene signature that accurately predicts the functioning of P53 variants, important information to assessing cancer risk and optimizing choices for cancer therapeutics.

7 Feb 2023

New hexameric structure of the protein triggering antibiotic resistance discovered

All living organisms require DNA replication to ensure the genetic integrity of the following generation. On the other hand, bacteria have the ability to horizontally transfer genetic information to other bacteria.

6 Feb 2023

Groundbreaking discovery could lead to new ways of controlling gene regulation

UT Southwestern Medical Center researchers have discovered a method cells use to turn genes on and off that involves portions of proteins whose function has long been a mystery.

6 Feb 2023

Employing molecular anchor for more effective CAR immunotherapies

Researchers at St. Jude Children’s Research Hospital discovered that immune cells with the attached protein boosted the killing of cancer, irrespective of the kind of cancer cell or the type of cancer being targeted.

3 Feb 2023

Experimental optimization of prime editing to achieve high efficiency

Genome editing technologies have enormous potential for treating genetic diseases. Techniques like the extensively used CRISPR/Cas9 gene scissors target the source of the disease directly in the DNA.

3 Feb 2023

Scientists unravel the physics of a cellular process linked to aggregation diseases

Researchers from Princeton University have uncovered the physics of a cellular process linked to aggregation diseases including Huntington's disease, paving the way to a deeper understanding of neurodegenerative disorders at the molecular level.

3 Feb 2023

RNA-G quadruplexes in living cells: A real-time study

Amyotrophic lateral sclerosis (ALS), sometimes referred to as Stephen Hawking’s disease and Lou Gehrig’s disease is a neurological condition that causes the body’s muscles to gradually lose control.

2 Feb 2023

Scientists define four cancer molecular subtypes using PDX models

Metastasis, the process by which cancer cells leave the primary tumor and spread to other tissues to seed new cancerous growth, causes most cancer deaths.

2 Feb 2023

Study uncovers a link between the genetic instructions for production and perception of sex pheromones

It's almost Valentine's Day, and love is in the air. Or in the waxy coating on your skin, if you are a vinegar fly. That's where flies encounter pheromones that play an important role in regulating sexual attraction.

1 Feb 2023

Learning about cellular proteins through “snapshots” of translation

Pep-tRNAs, nascent polypeptides inside the ribosome that are covalently connected to transfer RNA, are engaged in a variety of cell processes, including gene expression, according to advances in molecular biology.

1 Feb 2023

Tweezers illustrate how chemotherapy affects DNA

A recent study from Cornell University offers a new perspective on how the chemotherapy agent etoposide delays and kills vital enzymes that support the growth of cancer cells.

31 Jan 2023

Novel, more accurate computational tool for long-read RNA sequencing developed

On the journey from gene to protein, a nascent RNA molecule can be cut and joined, or spliced, in different ways before being translated into a protein.

31 Jan 2023

Molecular staple: The DNA repair mechanism impeding cancer treatment

Due to the continuous cellular activity, malfunctions frequently occur, making error-correcting systems crucial for cells. However, it serves the cancer cells’ best interests to cause errors when it comes to destroying them.

30 Jan 2023

Novel protein degradation technology provides functional insights into how CTCF regulates transcription

CTCF is a critical protein known to play various roles in key biological processes such as transcription.

30 Jan 2023

Cryo-EM helps visualize the detailed structure of viral genome replication machinery

RNA viruses, such as the coronavirus that causes COVID-19, are in a life-and-death race the moment they infect a cell.

30 Jan 2023

Evolution of mint plants' chemistry could lead to new medicines, pesticides

The mint family of herbs, which includes sage, rosemary, basil, and even woody plants like teak, offers an invigorating jolt to our senses of smell and taste.

27 Jan 2023

Molecular & Structural Biology

A protein in the lung forms a natural protective barrier against SARS-CoV-2 infection

Protein-rich droplets in cells linked to many unresolved diseases

Semi-quantitative system employs eDNA to detect endangered species

Study elucidates the structure of centromeric region in chicken cells

Newly discovered gene signature accurately predicts the functioning of P53 variants

New hexameric structure of the protein triggering antibiotic resistance discovered

Groundbreaking discovery could lead to new ways of controlling gene regulation

Employing molecular anchor for more effective CAR immunotherapies

Experimental optimization of prime editing to achieve high efficiency

Scientists unravel the physics of a cellular process linked to aggregation diseases

RNA-G quadruplexes in living cells: A real-time study

Scientists define four cancer molecular subtypes using PDX models

Study uncovers a link between the genetic instructions for production and perception of sex pheromones

Learning about cellular proteins through “snapshots” of translation

Tweezers illustrate how chemotherapy affects DNA

Novel, more accurate computational tool for long-read RNA sequencing developed

Molecular staple: The DNA repair mechanism impeding cancer treatment

Novel protein degradation technology provides functional insights into how CTCF regulates transcription

Cryo-EM helps visualize the detailed structure of viral genome replication machinery

Evolution of mint plants' chemistry could lead to new medicines, pesticides

How Avatar Medical's 3D Technology Is Transforming How We Visualize the Human Body

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

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