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New Karyoptosis Mechanism Linked to Alzheimer's and Frontotemporal Dementia

Markers of a new mechanism for cell death, called karyoptosis, have been found in brains of patients with Alzheimer's disease and frontotemporal dementia (FTD).

26 Jun 2026

Researchers Outline Dynamic Protein Control Systems for Better Clinical Decisions

Cancer has often been explained through mutations in deoxyribonucleic acid (DNA) or changes in ribonucleic acid (RNA), but these layers do not fully explain why tumors with similar genetic profiles can behave differently.

10 Jun 2026

Cell Phase Separation Creates Droplets That Optimize and Activate Kinase Signaling

Within the past decade, biologists have discovered that one strategy cells use to keep their contents organized is a phenomenon known as phase separation.

2 Jun 2026

Study Connects Lysosomal Lipid Movement Directly to Cellular Growth Signaling

While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for the metabolite. Some tumor cells use as much cholesterol as they can access to accelerate their growth beyond the capabilities of normal cells.

25 May 2026

Animals Adapt Rapidly Through Protein Networks, Not Genes

UT Southwestern Medical Center researchers have discovered a key molecular mechanism that allows animals to adapt to changing environmental conditions without altering their genes – an ability known as phenotypic plasticity.

15 May 2026

New Study Reveals Mechanism Behind Early Plant Cell Wall Development

Cell walls are a crucial structure of plant life, protecting cells from damage, giving plants shape, and containing energy-rich nutrients. And yet the process of how the walls begin to form remains mysterious.

5 May 2026

How the Microbiome Shapes Cancer Immunity and Therapy Response

This review examines how the human microbiome regulates anti-tumor immunity through DNA damage, inflammation, immune-cell activity, microbial metabolites, and tumor microenvironment remodeling. It highlights emerging microbiome-based strategies, including FMT, probiotics, prebiotics, engineered bacteria, and live biotherapeutics, while stressing the need for rigorous validation and clinical trials.

29 Apr 2026

Proxygen Expands Platform Beyond Degradation to Build Next-Generation Induced Proximity Therapeutics

Proxygen, a biotechnology company pioneering the discovery of molecular glue degraders and next-generation proximity-based therapeutics, today publicly announced the expansion of its platform beyond targeted protein degradation to access a broader range of induced proximity therapeutics, while advancing two lead molecular glue degrader programs toward clinical development.

From Proxygen 29 Apr 2026

Key Protein Switch Activates Leptospira Virulence and Disease Spread

During infection, pathogens must adapt quickly to the conditions to thrive inside the body. A research team at the University of Basel, Switzerland, has uncovered how a key protein switches on the machinery that enables Leptospira pathogens to survive and cause disease.

28 Apr 2026

How Mitochondrial Damage Accelerates Stem Cell Aging

Hematopoietic stem cells (HSCs), the cells that produce all blood cell types, start to lose their efficacy as one ages, which eventually reduces the ability to maintain healthy blood and a robust immune system.

17 Apr 2026

New Genetic Pathways and Compounds Identified to Prevent Cone Degeneration

Scientists led by Botond Roska at the Institute of Molecular and Clinical Ophthalmology Basel (IOB) and collaborators have identified genetic pathways and compounds capable of protecting cone photoreceptors from the degeneration that underlies conditions like age-related macular degeneration.

30 Mar 2026

Microtubules Act as Active Regulators of Key Cellular Enzymatic Reactions

Microtubules, the dynamic filaments that form the cell's internal scaffolding, have long been viewed as mere passive structural supports. But a new study reveals they play a far more active signaling role.

27 Mar 2026

Gut Microbes Reshape Ovarian Aging in Mice

Findings indicate gut microbes impact ovarian function in mice, offering insights into reproductive aging and potential microbiome-based health interventions.

12 Mar 2026

Engineered E. coli Produces Key Plant Compound at Record Levels

Researchers engineered E. coli to produce orsellinic acid-derived meroterpenoids, offering a sustainable alternative to traditional plant extraction methods.

25 Feb 2026

Brain Enzymes MNK1 and MNK2 Regulate Distinct Behaviors in the Brain

Researchers at the Max Delbrück Center show that two related enzymes, MNK1 and MNK2, act on the brain to regulate different behaviors.

20 Feb 2026

Water Pressure Mechanism Enables Rapid Cancer Cell Migration

Cancer is one of the leading causes of death worldwide, marked by the uncontrolled growth of abnormal cells.

9 Feb 2026

Single Enzyme Enables Low-Cost Synthesis of All RNA Nucleotides

A single enzyme that can generate all four nucleotide triphosphates, the building blocks of ribonucleic acid (RNA), was identified by researchers at the Institute of Science Tokyo.

24 Jan 2026

Elusive Kinase State Explains How Cells Achieve Efficient Signaling

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its target, without needing to release

19 Dec 2025

Study Reveals ATM-Driven Mechanism Behind Telomere-Induced Senescence

After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres-the protective caps at the chromosome ends-those caps eventually become too short to prevent chromosome ends from being recognized as DNA breaks.

2 Dec 2025

UBQLN2 Liquid Droplets Found to Catalyze Early α-Synuclein Aggregation

Parkinson's disease (PD) is an age-related, progressive neurodegenerative disorder. The hallmark of PD pathogenesis is the Lewy bodies (LBs) that accumulate in neurons in the substantia nigra region of the brain, damaging these neurons and leading to the motor symptoms of the disease. α-synuclein (α-syn), a misfolded protein, aggregates and forms fibrils, which leads to the formation of LBs.

27 Nov 2025