Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

Next-Generation RNA Therapeutic Approach Offers Hope for Treating Diverse Genetic Diseases

Researchers at the University of Toronto have developed a next-generation RNA therapeutic approach with the potential to treat a wide range of genetic diseases that share certain disease-causing mutations.

28 Aug 2026

Scientists Give Lab-Grown Brain Organoids a Regional Biological Compass

The human brain is often described as one of the most complex structures in biology, and much of its power comes from how it's organized.

21 Aug 2026

Tireless Stem Cells Drive Continuous Renewal Across High Friction Human Intestines

Digestion is hard on the cells that line the human gut, and they are constantly being shed and replaced. This renewal is driven by a population of tireless stem cells. These stem cells can both replace the various types of intestinal cells that have been lost as well as renew themselves.

6 Aug 2026

Kobe University Unveils Mass-Producible Off-the-Shelf Cancer Fighters

Off-the-shelf and mass-producible immune cells fight solid human tumors engrafted into mice. The Kobe University development is a significant contribution towards faster and cheaper cancer immunotherapy.

24 Jul 2026

Synthetic Organizer Cells To Build More Realistic Kidney Organoids

In research published in Science, USC researchers combined a biological finding with an engineering achievement to produce organoids—lab-grown kidney structures derived from stem cells—that are more faithful and reproducible.

3 Jul 2026

Stanford Researchers Find Dual Protein Mechanism Driving Psoriasis Inflammation

Two proteins with opposing functions orchestrate the development and maintenance of healthy skin, Stanford Medicine researchers have found.

26 Jun 2026

New Genetic Discovery Explains Why Colorectal Cancer Spreads so Quickly

Loss of GATA6-a transcription factor that controls which genes are turned on or off-can reprogram colorectal cancer cells into more primitive, adaptable states that can then spread to the liver and establish new tumors, according to Weill Cornell Medicine and Massachusetts Institute of Technology researchers.

23 Jun 2026

Scientists Discover Hidden Brain Development Signaling Pathway

The cytoskeleton gives cells their shape and helps them move. Researchers at Helmholtz Munich and the Ludwig Maximilian University now show that, in neural stem cells, proteins of the cytoskeleton are also found in the cell nucleus, where they can influence developmental programs.

23 Jun 2026

New Retinal Cell Discovery Paves Way for Sight-Restoring Transplants

A new understanding of retinal cell development may help pave the way for future retina transplants, which could restore sight to people whose conditions currently have no effective treatments, according to researchers at the Perelman School of Medicine at the University of Pennsylvania.

15 Jun 2026

Building More Realistic Human Tissue Models With Assembloids

Assembloids combine organoids and specialized cells, creating advanced models for drug testing and regenerative medicine with improved physiological relevance.

11 Jun 2026

New Cell Therapy Modifies Natural Killer Cells Against Cancer

Scientists have made great progress in harnessing the body's own immune cells to treat so-called liquid tumors, cancers of the blood and lymphatic system.

11 Jun 2026

Scientists Identify EHMT2 Enzyme as Main Cause of 5-FU Failure

One of the most widely used chemotherapeutic agents for colorectal cancer is 5-fluorouracil (5-FU), a cornerstone treatment that has improved outcomes for countless patients.

9 Jun 2026

Drug Boosts Axon Regrowth In Human Brain-Spinal Cord Model

This study presents a human organoid model that identifies genetic factors limiting nerve regeneration and highlights lynestrenol's role in promoting repair.

4 Jun 2026

Bispecific Antibodies Target Tumors While Sparing Healthy Tissue

A new generation of bispecific antibodies effectively targets cancer cells, minimizing toxicity and enhancing treatment precision in preclinical studies.

3 Jun 2026

Identifying a Genetic Switch That Halts Human Nerve Regeneration

Researchers at Cambridge have created tiny circuits in the lab that replicate the connections between the brain and spinal cord, which control human movements.

29 May 2026

Ovarian Cancer Fluid Helps Tumors Evade Cell Death

Ascites in ovarian cancer rewires tumor metabolism, protecting cells from ferroptosis and promoting metastasis, revealing potential therapeutic targets.

27 May 2026

Inflammatory Cytokines Trigger Higher Protein Levels as a Natural Defense Mechanism Against Disease

A new study from researchers at the University of Chicago provides important insight into how the pancreas protects itself during inflammation, pointing to promising new directions for treating pancreatitis.

23 May 2026

New 3D-Printed Trays Help Produce Functioning Human Gut Organoids Twice as Fast

Thanks to special 3D-printed scaffolding trays designed by experts at Cincinnati Children's, researchers can now produce larger versions of functional human gut organoids twice as fast as previous methods-and these organoids grow their own nerve cells.

23 May 2026

New 3D Cortical Tissue Models Incorporate Microglia to Bridge Preclinical Translation Gaps

28bio today announced CNS-3D Inflammatory Organoids, designed to evaluate efficacy of anti-inflammatory drugs by quantifying their ability to reduce inflammatory injury, preserve tissue health, and restore neuronal network activity.

20 May 2026

New Non-Destructive Method Obtains Genetic Information From Living Cells

Normally, cells must be lysed for a so-called transcriptome analysis - which reveals which genes are currently being expressed - making repeated measurements on the same cells impossible.

7 May 2026