Efficacy News and Research

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New Method for Engineering GPCRs Opens Pathways for Advanced Drug Development

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions.

24 Jan 2025

AI-designed proteins revolutionize snakebite treatment

Research highlights the potential of deep learning in creating proteins that neutralize snake venom, offering new solutions for neglected tropical diseases.

24 Jan 2025

Gene-Edited Bacteria Increases Nitrogen Fixation in Corn

If corn ever felt envious of soybean’s relationship with nitrogen-fixing bacteria, advancements in gene editing may one day level the playing field.

17 Jan 2025

AI-Powered Platform for Designing Novel Protein Interactions

Researchers at EPFL have opened up a world of possibilities in the computational design of molecular interactions for biomedicine by using deep learning to create new proteins that bind to complexes involving other small molecules, such as hormones or medications.

17 Jan 2025

New Study Offers Hope for Safer, More Effective Snakebite Treatment

Last year’s Chemistry Nobel Laureate published a new study in Nature that could revolutionize the way snakebite is treated.

16 Jan 2025

Study Reveals T Cells as Key Players in Complete Viral Infection Control

Scientists from Duke-NUS Medical School and the Singapore General Hospital have discovered that T cells-white blood cells that can destroy harmful pathogens-can completely prevent viral infection, to an extent previously thought only possible due to neutralizing antibodies.

13 Jan 2025

Weak Molecular Interactions Trigger Autophagy in Cells

Recycling takes place in our cells at all times: in a process called autophagy, cell components that are no longer needed are enclosed by membranes and broken down into their basic building blocks.

8 Jan 2025

Zinc Stress Exposes Vulnerabilities in Drug-Resistant Bacteria

McMaster University researchers have identified zinc or the lack of it as a crucial weakness in drug-resistant bacteria.

7 Jan 2025

NIH Study Reveals Potent Antibodies for Malaria Prevention

A novel class of antibodies that binds to a previously untargeted portion of the malaria parasite could lead to new prevention methods, according to a study from researchers at the National Institutes of Health (NIH) published today in Science.

6 Jan 2025

Novel Vaccine Adjuvant with Potent Immunostimulatory Properties

Researchers from JCU have discovered particles in the well-known “superfood” spirulina that may significantly improve the efficacy and production of vaccines.

3 Jan 2025

New Platform Simplifies Protein-Protein Interaction Measurements

A team led by researchers at the University of Toronto has created a platform, called SIMPL2, that revolutionizes the study of protein-protein interactions by simplifying detection while improving measurement accuracy.

26 Dec 2024

Discovery of ALAS1's Secret Role Could Boost Cancer Therapy Development

In everyday life, when things turn out the opposite of what you expect, it's usually cause for frustration. In science, it's often the starting point for discovery.

23 Dec 2024

Scientists Discover Key to Overcoming Cancer's Evasion Tactics

A cunning culprit that aids cancer cells in avoiding CAR T cell therapy has been identified by researchers at City of Hope®, one of the biggest and most cutting-edge cancer research and treatment organizations in the United States, with a comprehensive cancer center in Los Angeles that is ranked among the top five cancer centers in the country by US News & World Report.

18 Dec 2024

A revolutionary antibody approach to fight cancer by restoring cellular fitness

Ovarian cancer cells exploit cell competition by altering Flower protein isoforms in stromal cells, promoting tumor survival and potential therapeutic targets.

18 Dec 2024

Exosome-Mediated Immune Escape and Tumor Growth in Hepatocellular Carcinoma

The TIME is a dynamic network composed of cancer cells, immune cells, and stromal components. During the early stages of tumorigenesis, the TIME attempts to eliminate abnormal cells through immune surveillance.

12 Dec 2024

Genetic Mutation in the Inherited DNA Found to Drive Breast Cancer Metastasis

Ninety percent of cancer deaths are due to the spread of cancer, not complications from the original tumor.

10 Dec 2024

Comprehensive Review of Intracellular Checkpoints in NK Cell Biology and Cancer

Natural killer (NK) cells play an important role in the innate immune response to cancer and viral infections, and their presence in tumors correlates with improved patient outcomes in a variety of cancers.

29 Nov 2024

New Light-Driven Biohybrid System Supports Precise Photoimmunotherapy

In a study published in Cell Reports Physical Science on Nov. 25, a research team led by Prof. CAI Lintao from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences reported its development of an innovative intelligent light-guided biohybrid system, the CTPA/siCSF1R system, to target tumor-associated macrophages (TAMs), thus enabling precise spatiotemporal siRNA delivery.

28 Nov 2024

LysoTRAP Strategy Offers Hope for Clearing Viral Infections Across Variants

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences have recently developed a novel lysosomal strategy for clearing viruses and their variants.

28 Nov 2024

Immunotherapy Advances: CAR T Cells Targeting GD2 Offer Hope for Glioma Patients

Findings suggest GD2-specific CAR T-cell therapy is a viable option for H3K27M-mutant gliomas, with significant tumor shrinkage and clinical benefits observed.

22 Nov 2024