Efficacy News and Research

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How CRISPRi is Helping Combat Drug-Resistant Tuberculosis

Findings on isoniazid-resistant M. tuberculosis reveal key vulnerabilities, suggesting new avenues for treatment strategies against drug-resistant tuberculosis.

20 Nov 2024

A Closer Look at CAR T-Cell Therapy — Successes, Challenges, And Future

Chimeric antigen receptor T-cell therapy enhances immune response against cancer, with promising results in hematological malignancies and ongoing advancements.

13 Nov 2024

Drug Adsorption on Nano-Plastics: Could Plastic Particles Reduce Antibiotic Efficacy?

Interactions between tetracycline and nano-plastics alter drug stability and bioavailability, raising concerns about antibiotic resistance in ecosystems.

11 Nov 2024

UAB Develops a Polygenic Score to Predict Cancer Drug Resistance

In 1937, President Franklin Roosevelt signed the National Cancer Act, launching a nationwide effort to combat the disease.

8 Nov 2024

New Discovery Shows TAGLN2 Protein Boosts T Cell Immunity Against Tumors by Enhancing Lipid Metabolism

Findings indicate ovarian cancer disrupts CD8+ T cell metabolism through FABP5 and TAGLN2, suggesting new therapeutic targets for enhancing immune function.

1 Nov 2024

Novel Approach to Predict and Optimize CAR-T Cell Therapy

A significant turning point in the battle against cancer has been the recent development of CAR-T technology.

30 Oct 2024

Encrypted Peptides Offer Hope Against Antibiotic-Resistant Infections

Researchers have discovered a new class of antimicrobial compounds called encrypted peptides, which could boost the immune system's toolkit to combat infection and counteract the growing problem of antibiotic-resistant bacteria.

29 Oct 2024

Researchers Identify Mechanism of Immune Suppression in Ovarian Cancer

Researchers at Weill Cornell Medicine have shown that ovarian cancers disable immune cells and prevent them from attacking by cutting off the energy source that T cells rely on.

24 Oct 2024

Targeting Fat Metabolism Enhances Ferroptosis-Inducing Cancer Treatments

According to a study conducted by researchers at the Van Andel Institute, preventing cancer cells from obtaining fat may improve the efficacy of a particular cancer treatment.

23 Oct 2024

Phages Form Unique 3D Shapes, Boosting Disease Detection

While preparing slides to be examined under a powerful microscope, a team of McMaster researchers who frequently work with bacteriophage viruses that consume bacteria had a pleasant and potentially very significant surprise.

22 Oct 2024

EVQ-218: A Promising Candidate for Tackling Superbugs Without Triggering Antimicrobial Resistance

As the United Nations (UN) prepares to address the escalating threat of antimicrobial resistance, EVŌQ Nano is helping raise awareness through an educational infographic depicting a common trigger of antimicrobial resistance and highlighting EVQ-218's novel mechanism of action.

18 Oct 2024

Melanin May Act as a "Drug Sponge," Influencing Medication Effectiveness

Skin pigmentation may act as a "sponge" for some medications, potentially influencing the speed with which active drugs reach their intended targets, a pair of scientists report in a perspective article published in the journal Human Genomics.

15 Oct 2024

African Wormwood Identified as Potential Weapon Against Drug-Resistant Tuberculosis

The mechanisms through which A. afra fights M. tuberculosis.

14 Oct 2024

Bacterial Gene Expression Drives the Evolution of Antibiotic Resistance

As strains of pathogens resistant to frontline antibiotics become more common worldwide, clinicians are more often turning to combination treatments that degrade this resistance as a first treatment option.

14 Oct 2024

CAR-NKT Cells Show Promise in Overcoming Solid Tumor Barriers

Chimeric antigen receptor T-cell therapy (CAR-T) has shown significant promise in the treatment of blood malignancies in the fight against cancer.

8 Oct 2024

Fighting Drug-Resistant TB with a Novel Antibiotic

A novel semi-synthetic molecule that produces significant activity against strains of Mycobacterium tuberculosis, including those that are resistant to drugs, can be generated from natural compounds according to a study published in the American Society for Microbiology journal Microbiology Spectrum.

4 Oct 2024