Liquid Chromatography News and Research

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Evosep and Molecular You Announce Strategic Collaboration to Scale Standardized Multi-Omic Testing Globally

Evosep and Molecular You today announced a strategic collaboration to advance standardized, high-throughput multi-omic testing for personalized biomarker profiling.

From Evosep 3 Jun 2026

Ovarian Cancer Fluid Helps Tumors Evade Cell Death

Ascites in ovarian cancer rewires tumor metabolism, protecting cells from ferroptosis and promoting metastasis, revealing potential therapeutic targets.

27 May 2026

Can Everyday Supplements Lead to Failed Anti-Doping Tests?

Researchers developed a high-throughput LC-MS/MS platform that screened 331 pharmacologically active compounds and quantitatively validated 214 analytes across representative food matrices. Applied to 78 commercial foods and supplements, the framework showed that some products could produce modeled urinary concentrations exceeding WADA reporting thresholds under realistic intake scenarios.

19 May 2026

Next-Generation Mass Spectrometry Reveals How DIA Deepens Proteome Coverage

A multivendor comparison in a neonatal mouse model of bronchopulmonary dysplasia found that DIA, especially on next-generation platforms such as Orbitrap Astral and timsTOF Ultra, greatly expanded peptide and protein detection while preserving broad biological concordance. The deeper coverage improved subcellular and pathway annotation, increased differential protein detection, and reduced estimated sample-size needs, although platform-specific technical differences still complicated direct comparisons.

19 Apr 2026

A Python-Inspired Molecule Suppresses Appetite After Eating

The study identifies pTOS as a key metabolite in appetite suppression, highlighting a gut–liver–brain pathway with implications for obesity therapy.

2 Apr 2026

Shimadzu’s Design Craftech - Fusing Traditional Kyoto Craft Techniques with Industrial Production

Shimadzu Corporation, which was celebrating its 150th anniversary in 2025, has a long history of involvement with traditional Kyoto crafts dating back to its origins as a maker of Buddhist altar fittings.

From Shimadzu Europa GmbH 27 Mar 2026

Reversing Memory Loss in Aging Mice by Targeting Gut Bacteria

The study uncovers how gut bacteria like Parabacteroides goldsteinii contribute to memory decline, offering insights for potential cognitive interventions.

26 Mar 2026

Turning Plastic Bottles into Levodopa, a Key Parkinson’s Treatment

This study demonstrates the conversion of plastic bottles into levodopa using engineered bacteria, highlighting a novel approach to sustainable drug production.

25 Mar 2026

Gut Microbes Reshape Ovarian Aging in Mice

Findings indicate gut microbes impact ovarian function in mice, offering insights into reproductive aging and potential microbiome-based health interventions.

12 Mar 2026

How SARS-CoV-2 Hijacks Host tRNA Chemistry to Sustain Infection

Findings reveal coronaviruses exploit stress-linked tRNA modifications, enhancing translation efficiency and offering insights for antiviral drug development.

11 Mar 2026

Blood Tau217 Test Predicts When Alzheimer’s Symptoms May Begin

The %p-tau217 biomarker in blood offers a novel approach to estimate Alzheimer's onset, potentially transforming prevention trial strategies.

5 Mar 2026

Engineered E. coli Produces Key Plant Compound at Record Levels

Researchers engineered E. coli to produce orsellinic acid-derived meroterpenoids, offering a sustainable alternative to traditional plant extraction methods.

25 Feb 2026

Nearly 1/3 of Pesticides and Industrial Chemicals Harm Gut Bacteria

A study reveals that common pesticides and industrial chemicals inhibit gut bacteria, highlighting risks to health and the need for revised safety assessments.

5 Dec 2025

‘Forever chemicals’ build up in British Columbia sea otters

PFAS contamination in British Columbia sea otters underscores urban pollution's effects on marine life and the importance of long-term ecological monitoring.

12 Nov 2025

Scientists Engineer E. Coli To Produce Plastic-Building Chemical

This study reveals a novel pathway in E. coli for synthesizing 2,5-pyridinedicarboxylate from glucose, offering a sustainable alternative to fossil fuels.

10 Sep 2025

How Defined Microbes Decide Chocolate Flavor

This study links microbial activity and fermentation conditions to cocoa flavor profiles, advancing techniques for producing premium chocolate consistently.

27 Aug 2025

Collagen and Chitin Amendments Support Soil Microbes to Control Nematode Infections

Collagen and chitin shift soil microbial communities and reduce root-knot nematode infections in tomato plants while improving plant growth and chlorophyll content.

23 Jun 2025

Addressing Protein Leakage in Cells to Improve the Accuracy of Single-Cell Proteomic Data

A new study in Nature Communications presents a solution to protein leakage in single-cell proteomics, improving data quality by identifying and excluding permeabilized cells using a machine learning classifier.

19 May 2025

Depleting TM6SF2 in the Gut Worsens Liver Fat Buildup, Study Finds

A new study finds that gut-specific TM6SF2 depletion exacerbates liver fat accumulation and dysbiosis in mice on high-fat diets, highlighting its importance in gut-liver metabolic regulation.

12 May 2025

Dangerous Synthetic Opioids and Animal Sedatives Not Approved for Human Use Have Been Found in Australia's Wastewater

University of South Australia scientists have developed a highly sensitive method to detect illegal opioids and a veterinary sedative in Australia’s wastewater system, providing a vital early warning tool to public health authorities.

28 Apr 2025